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2009 ; 9
(ä): 133-6
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The N-terminal domain of thrombospondin-1: a key for the dual effect of TSP-1 in
angiogenesis and cancer progression?
#MMPMID19219378
Morandi V
ScientificWorldJournal
2009[Feb]; 9
(ä): 133-6
PMID19219378
show ga
The data presented in this article suggest that intact TSP-1 may act, in normal
vessel homeostasis, as an angiostatic factor favoring vessel quiescence, or even
vessel regression, but this activity would be largely impaired in the presence of
an excess of angiogenic stimuli and proteases. The fact that the N-terminal
domain of TSP-1 (heparin-binding domain or HBD) is recognized by a plethora of
cell receptors, all of them engaged in proangiogenic responses, strongly suggests
that the proteolytic cleavage of HBD may be relevant in certain
pathophysiological conditions.