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10.1155/2018/2670312 http://scihub22266oqcxt.onion/10.1155/2018/2670312 C5822862!5822862 !29581966     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29581966 &cmd=llinks): Failed to open stream: HTTP request failed! 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Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension |pdf=|usr=}}{{29581966 }} gab.com Text Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=29581966 #FOAvip BACKGROUND: There is accumulating evidence pointing to uremia-induced impairment of the intestinal epithelial barrier structure in advanced chronic kidney disease (CKD) and hemodialysis (HD) patients. In this study, the impact of intradialytic hypotension on intestinal barrier integrity is being explored. METHODS: Immunohistochemical staining was used to detect the expression of 4 types of tight junction (TJ) proteins such as occludin, zonula occludens-1 (ZO-1), claudin-1, and claudin-4, in colonic samples of a group of patients receiving segmental colectomy. Five patients with nondialysis CKD (group 2), 5 HD patients with intradialytic hypotension (group 3), and 5 non-CKD subjects (group 1) were examined. RESULTS: Both patients' groups 2 and 3 demonstrated significantly reduced expression of occludin as compared to group 1 (p < 0.05 and p < 0.01, resp.). Except for claudin-4, expression of all markers of TJ proteins was significantly reduced in patients' group 3 as compared to control (p < 0.01). In addition, decreased expressions of claudin-1 and ZO-1 were also more pronounced in group 3 when compared to group 2. CONCLUSIONS: This study extends the earlier finding by demonstrating that dialysis-related hypotension caused even marked depletion of the key protein constituents of the epithelial TJ. Twit Text FOAVip Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=29581966 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29581966 #FOAvip English Wikipedia <ref>{{Cite pmid|29581966 }}</ref> Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Patients Complicated with Intradialytic Hypotension #MMPMID29581966 Wu TK ; Lim PS ; Jin JS ; Wu MY ; Chen CH Biomed Res Int 2018[]; 2018 (ä): 2670312 PMID29581966 show ga BACKGROUND: There is accumulating evidence pointing to uremia-induced impairment of the intestinal epithelial barrier structure in advanced chronic kidney disease (CKD) and hemodialysis (HD) patients. In this study, the impact of intradialytic hypotension on intestinal barrier integrity is being explored. METHODS: Immunohistochemical staining was used to detect the expression of 4 types of tight junction (TJ) proteins such as occludin, zonula occludens-1 (ZO-1), claudin-1, and claudin-4, in colonic samples of a group of patients receiving segmental colectomy. Five patients with nondialysis CKD (group 2), 5 HD patients with intradialytic hypotension (group 3), and 5 non-CKD subjects (group 1) were examined. RESULTS: Both patients' groups 2 and 3 demonstrated significantly reduced expression of occludin as compared to group 1 (p < 0.05 and p < 0.01, resp.). Except for claudin-4, expression of all markers of TJ proteins was significantly reduced in patients' group 3 as compared to control (p < 0.01). In addition, decreased expressions of claudin-1 and ZO-1 were also more pronounced in group 3 when compared to group 2. CONCLUSIONS: This study extends the earlier finding by demonstrating that dialysis-related hypotension caused even marked depletion of the key protein constituents of the epithelial TJ. |*Gene Expression Regulation [MESH] |*Hypotension/metabolism/pathology [MESH] |*Intestinal Mucosa/metabolism/pathology [MESH] |*Renal Dialysis [MESH] |*Renal Insufficiency, Chronic/metabolism/pathology/therapy [MESH] |*Tight Junctions/metabolism/pathology [MESH] |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Female [MESH] |Humans [MESH] |Male [MESH] |Middle Aged [MESH]Impaired Gut Epithelial Tight Junction Expression in Hemodialysis Pati(epmc).pdf DeepDyve Pubget Overpricing