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10.1371/journal.pone.0192361 http://scihub22266oqcxt.onion/10.1371/journal.pone.0192361 C5821337!5821337!29466390     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+One 2018 ; 13 (2): ä Nephropedia Template TP {{tp|p=29466390|t=2018. The role of complement activation in rhabdomyolysis-induced acute kidney injury |pdf=|usr=}}{{29466390}} gab.com Text The role of complement activation in rhabdomyolysis-induced acute kidney injury JO: PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29466390 #FOAvip Rhabdomyolysis (RM) may cause kidney damage and results primarily in acute kidney injury (AKI). Complement is implicated in the pathogenesis of renal diseases and ischemia-reperfusion injury (IRI), but the role of complement, especially its activation pathway(s) and its effect in RM-induced AKI, is not clear. This study established a rat model of AKI induced by RM via intramuscular treatment with glycerol. Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol. We found that the complement components, including complement 3 (C3), C1q, MBL-A, factor B(fB), C5a, C5b-9, and CD59, were significantly increased in rat kidneys after intramuscular glycerol administration. However, the levels of serum BUN and Cr, renal tubular injury scores, and the number of TUNEL-positive cells decreased significantly in the CVF+AKI group. These results suggest that complement plays an important role in RM-induced AKI and that complement depletion may improve renal function and decrease renal tissue damage by reducing the inflammatory response and apoptosis. Twit Text FOAVip The role of complement activation in rhabdomyolysis-induced acute kidney injury ????PLoS One http://www.kidney.de/pget.php?&tw=1&pmid=29466390 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29466390 #FOAvip English Wikipedia <ref>{{Cite pmid|29466390}}</ref> The role of complement activation in rhabdomyolysis-induced acute kidney injury #MMPMID29466390 Huang X; Zhao W; Zhang L; Yang X; Wang L; Chen Y; Wang J; Zhang C; Wu G PLoS One 2018[]; 13 (2): ä PMID29466390show ga Rhabdomyolysis (RM) may cause kidney damage and results primarily in acute kidney injury (AKI). Complement is implicated in the pathogenesis of renal diseases and ischemia-reperfusion injury (IRI), but the role of complement, especially its activation pathway(s) and its effect in RM-induced AKI, is not clear. This study established a rat model of AKI induced by RM via intramuscular treatment with glycerol. Cobra venom factor (CVF) was administered via tail vein injection to deplete complement 12 h prior to intramuscular injection of glycerol. We found that the complement components, including complement 3 (C3), C1q, MBL-A, factor B(fB), C5a, C5b-9, and CD59, were significantly increased in rat kidneys after intramuscular glycerol administration. However, the levels of serum BUN and Cr, renal tubular injury scores, and the number of TUNEL-positive cells decreased significantly in the CVF+AKI group. These results suggest that complement plays an important role in RM-induced AKI and that complement depletion may improve renal function and decrease renal tissue damage by reducing the inflammatory response and apoptosis. äThe role of complement activation in rhabdomyolysis-induced acute kidn(epmc).pdf DeepDyve Pubget Overpricing