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10.1172/jci.insight.95396 http://scihub22266oqcxt.onion/10.1172/jci.insight.95396 C5821171!5821171!29415882     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29415882&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       JCI+Insight ä ; 3 (3): ä Nephropedia Template TP {{tp|p=29415882|t=ä. Swiprosin-1 deficiency impairs macrophage immune response of septic mice |pdf=|usr=}}{{29415882}} gab.com Text Swiprosin-1 deficiency impairs macrophage immune response of septic mice JO: JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29415882 #FOAvip Despite the fact that many therapeutic strategies have been adopted to delay the development of sepsis, sepsis remains one of the leading causes of death in noncoronary intensive care units. Recently, sepsis-3 was defined as life-threatening organ dysfunction due to a dysregulated host response to infection. Here, we report that swiprosin-1 (also known as EFhd2) plays an important role in the macrophage immune response to LPS-induced or cecal ligation and puncture?induced (CLP-induced) sepsis in mice. Swiprosin-1 depletion causes higher mortality, more severe organ dysfunction, restrained macrophage recruitment in the lung and kidney, and attenuated inflammatory cytokine production (including IL-1?, IL-6, TNF-?, IL-10, and IFN-?). The immunosuppression caused by swiprosin-1 deficiency is manifested by impaired bactericidal capacity and decreased HLA-DR expression in macrophages. Swiprosin-1 affects the activation of the JAK2/STAT1/STAT3 pathway by regulating the expression of IFN-? receptors in macrophages. Our findings provide a potential target for the regulation of the macrophage immune response in sepsis. Twit Text FOAVip Swiprosin-1 deficiency impairs macrophage immune response of septic mice ????JCI Insight http://www.kidney.de/pget.php?&tw=1&pmid=29415882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29415882 #FOAvip English Wikipedia <ref>{{Cite pmid|29415882}}</ref> Swiprosin-1 deficiency impairs macrophage immune response of septic mice #MMPMID29415882 Zhang S; Tu Y; Sun YM; Li Y; Wang RM; Cao Y; Li L; Zhang LC; Wang ZB JCI Insight ä[]; 3 (3): ä PMID29415882show ga Despite the fact that many therapeutic strategies have been adopted to delay the development of sepsis, sepsis remains one of the leading causes of death in noncoronary intensive care units. Recently, sepsis-3 was defined as life-threatening organ dysfunction due to a dysregulated host response to infection. Here, we report that swiprosin-1 (also known as EFhd2) plays an important role in the macrophage immune response to LPS-induced or cecal ligation and puncture?induced (CLP-induced) sepsis in mice. Swiprosin-1 depletion causes higher mortality, more severe organ dysfunction, restrained macrophage recruitment in the lung and kidney, and attenuated inflammatory cytokine production (including IL-1?, IL-6, TNF-?, IL-10, and IFN-?). The immunosuppression caused by swiprosin-1 deficiency is manifested by impaired bactericidal capacity and decreased HLA-DR expression in macrophages. Swiprosin-1 affects the activation of the JAK2/STAT1/STAT3 pathway by regulating the expression of IFN-? receptors in macrophages. Our findings provide a potential target for the regulation of the macrophage immune response in sepsis. äSwiprosin-1 deficiency impairs macrophage immune response of septic mi(epmc).pdf DeepDyve Pubget Overpricing