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10.1155/2018/2157434 http://scihub22266oqcxt.onion/10.1155/2018/2157434 C5820544!5820544!29568481     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Inflam 2018 ; 2018 (ä): ä Nephropedia Template TP {{tp|p=29568481|t=2018. Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus |pdf=|usr=}}{{29568481}} gab.com Text Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus JO: Int J Inflam http://www.kidney.de/pget.php?&tw=1&pmid=29568481 #FOAvip Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNF? (p < 0.01) and expression of CD11b (p < 0.001) and TLR4 (p < 0.001) compared to those in monocytes from healthy subjects. Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy supernatants, while expression levels of CD163 were found to be downregulated on monocytes from T2DM (p < 0.001) suggesting impaired ability of monocytes to switch their phenotype to anti-inflammatory. Taken together, our results suggest compromised function of monocytes in T2DM, which may explain, at least partly, high incidence of infection in these patients. Twit Text FOAVip Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus ????Int J Inflam http://www.kidney.de/pget.php?&tw=1&pmid=29568481 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29568481 #FOAvip English Wikipedia <ref>{{Cite pmid|29568481}}</ref> Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus #MMPMID29568481 Khondkaryan L; Margaryan S; Poghosyan D; Manukyan G Int J Inflam 2018[]; 2018 (ä): ä PMID29568481show ga Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNF? (p < 0.01) and expression of CD11b (p < 0.001) and TLR4 (p < 0.001) compared to those in monocytes from healthy subjects. Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy supernatants, while expression levels of CD163 were found to be downregulated on monocytes from T2DM (p < 0.001) suggesting impaired ability of monocytes to switch their phenotype to anti-inflammatory. Taken together, our results suggest compromised function of monocytes in T2DM, which may explain, at least partly, high incidence of infection in these patients. äImpaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus (epmc).pdf DeepDyve Pubget Overpricing