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10.1002/pros.23482 http://scihub22266oqcxt.onion/10.1002/pros.23482 C5820153!5820153!29341212     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Prostate 2018 ; 78 (5): 377-89 Nephropedia Template TP {{tp|p=29341212|t=2018. Differential Role of PTEN in Transforming Growth Factor ? (TGF-?) Effects on Proliferation and Migration in Prostate Cancer Cells |pdf=|usr=}}{{29341212}} gab.com Text Differential Role of PTEN in Transforming Growth Factor (TGF- ) Effects on Proliferation and Migration in Prostate Cancer Cells JO: Prostate http://www.kidney.de/pget.php?&tw=1&pmid=29341212 #FOAvip Background: Transforming growth factor -? (TGF-?) acts as a tumor suppressor in normal epithelial cells but as a tumor promoter in advanced prostate cancer cells. PI3-kinase pathway mediates TGF-? effects on prostate cancer cell migration and invasion. PTEN inhibits PI3-kinase pathway and is frequently mutated in prostate cancers. We investigated possible role(s) of PTEN in TGF-? effects on proliferation and migration in prostate cancer cells. Methods: Expression of PTEN mRNA and proteins were determined using RT-PCR and western blotting in RWPE-1 and DU145 cells. We also studied the role of PTEN in TGF? effects on cell proliferation and migration in DU145 cells after transient silencing of endogenous PTEN. Conversely, we determined the role of PTEN in cell proliferation and migration after over-expression of PTEN in PC3 cells which lack endogenous PTEN. Results: TGF-?1 and TGF-?3 had no effect on PTEN mRNA levels but both isoforms increased PTEN protein levels in DU145 and RWPE1 cells indicating that PTEN may mediate TGF-? effects on cell proliferation. Knockdown of PTEN in DU145 cells resulted in significant increase in cell proliferation which was not affected by TGF-? isoforms. PTEN overexpression in PC3 cells inhibited cell proliferation. Knockdown of endogenous PTEN enhanced cell migration in DU145 cells, whereas PTEN overexpression reduced migration in PC3 cells and reduced phosphorylation of AKT in response to TGF-?. Conclusion: We conclude that PTEN plays a role in inhibitory effects of TGF? on cell proliferation whereas its absence may enhance TGF-? effects on activation of PI3-kinase pathway and cell migration. Twit Text FOAVip Differential Role of PTEN in Transforming Growth Factor (TGF- ) Effects on Proliferation and Migration in Prostate Cancer Cells ????Prostate http://www.kidney.de/pget.php?&tw=1&pmid=29341212 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29341212 #FOAvip English Wikipedia <ref>{{Cite pmid|29341212}}</ref> Differential Role of PTEN in Transforming Growth Factor ? (TGF-?) Effects on Proliferation and Migration in Prostate Cancer Cells #MMPMID29341212 Kimbrough-Allah MN; Millena AC; Khan SA Prostate 2018[Apr]; 78 (5): 377-89 PMID29341212show ga Background: Transforming growth factor -? (TGF-?) acts as a tumor suppressor in normal epithelial cells but as a tumor promoter in advanced prostate cancer cells. PI3-kinase pathway mediates TGF-? effects on prostate cancer cell migration and invasion. PTEN inhibits PI3-kinase pathway and is frequently mutated in prostate cancers. We investigated possible role(s) of PTEN in TGF-? effects on proliferation and migration in prostate cancer cells. Methods: Expression of PTEN mRNA and proteins were determined using RT-PCR and western blotting in RWPE-1 and DU145 cells. We also studied the role of PTEN in TGF? effects on cell proliferation and migration in DU145 cells after transient silencing of endogenous PTEN. Conversely, we determined the role of PTEN in cell proliferation and migration after over-expression of PTEN in PC3 cells which lack endogenous PTEN. Results: TGF-?1 and TGF-?3 had no effect on PTEN mRNA levels but both isoforms increased PTEN protein levels in DU145 and RWPE1 cells indicating that PTEN may mediate TGF-? effects on cell proliferation. Knockdown of PTEN in DU145 cells resulted in significant increase in cell proliferation which was not affected by TGF-? isoforms. PTEN overexpression in PC3 cells inhibited cell proliferation. Knockdown of endogenous PTEN enhanced cell migration in DU145 cells, whereas PTEN overexpression reduced migration in PC3 cells and reduced phosphorylation of AKT in response to TGF-?. Conclusion: We conclude that PTEN plays a role in inhibitory effects of TGF? on cell proliferation whereas its absence may enhance TGF-? effects on activation of PI3-kinase pathway and cell migration. äDifferential Role of PTEN in Transforming Growth Factor ? (TGF-?) Effe(epmc).pdf DeepDyve Pubget Overpricing