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Cushing?s Disease ? Quality of Life, Recurrence and Long-term Morbidity #MMPMID29632565
Huguet I; Ntali G; Grossman A; Karavitaki N
Eur Endocrinol 2015[Apr]; 11 (1): 34-8 PMID29632565show ga
Cushing?s disease (CD) is a rare disorder caused by an adrenocorticotropic hormone (ACTH)-secreting pituitary adenoma. Chronic exposure to hypercortisolism leads to significant morbidities, which may be only partially reversible after remission of the disease, as well as to impairment of the health-related quality of life (HRQoL) and an increase in mortality. Transsphenoidal surgery (TSS) is the treatment of choice, and recurrence rates vary widely, confirming the need for lifelong follow-up. This review summarises the studies performed on HRQoL, recurrence rates and morbidities in patients who have CD.