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10.1073/pnas.1711977115 http://scihub22266oqcxt.onion/10.1073/pnas.1711977115 C5816149!5816149!29378968     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (7): 1611-6 Nephropedia Template TP {{tp|p=29378968|t=2018. Hippocampal expression of a virus-derived protein impairs memory in mice |pdf=|usr=}}{{29378968}} gab.com Text Hippocampal expression of a virus-derived protein impairs memory in mice JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29378968 #FOAvip As obligate parasites, viruses have evolved strategies to hijack cellular pathways and persist in their host, sometimes without causing overt diseases. As such, they represent unique tools to decipher cellular functions and their consequences on host physiology. Here, we exploited the natural property of a virus-encoded protein known to act as a decoy substrate for protein kinase C (PKC), a pathway thought to play key roles in learning and memory processes. When selectively expressed in the hippocampal dentate gyrus of mice, this protein caused behavioral abnormalities, notably increased anxiety and impaired memory, mostly by interfering with PKC-dependent phosphorylation. Our findings provide further insight into the role of the PKC pathway in controlling cognitive functions. Twit Text FOAVip Hippocampal expression of a virus-derived protein impairs memory in mice ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29378968 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29378968 #FOAvip English Wikipedia <ref>{{Cite pmid|29378968}}</ref> Hippocampal expression of a virus-derived protein impairs memory in mice #MMPMID29378968 Bétourné A; Szelechowski M; Thouard A; Abrial E; Jean A; Zaidi F; Foret C; Bonnaud EM; Charlier CM; Suberbielle E; Malnou CE; Granon S; Rampon C; Gonzalez-Dunia D Proc Natl Acad Sci U S A 2018[Feb]; 115 (7): 1611-6 PMID29378968show ga As obligate parasites, viruses have evolved strategies to hijack cellular pathways and persist in their host, sometimes without causing overt diseases. As such, they represent unique tools to decipher cellular functions and their consequences on host physiology. Here, we exploited the natural property of a virus-encoded protein known to act as a decoy substrate for protein kinase C (PKC), a pathway thought to play key roles in learning and memory processes. When selectively expressed in the hippocampal dentate gyrus of mice, this protein caused behavioral abnormalities, notably increased anxiety and impaired memory, mostly by interfering with PKC-dependent phosphorylation. Our findings provide further insight into the role of the PKC pathway in controlling cognitive functions. äHippocampal expression of a virus-derived protein impairs memory in mi(epmc).pdf DeepDyve Pubget Overpricing