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10.1038/mi.2017.55 http://scihub22266oqcxt.onion/10.1038/mi.2017.55 C5815964!5815964 !28812548     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28812548 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mucosal+Immunol 2018 ; 11 (2 ): 357-368 Nephropedia Template TP {{tp|p=28812548 |t=2018. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity |pdf=|usr=}}{{28812548 }} gab.com Text Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28812548 #FOAvip Interactions between the microbiota and distal gut are important for the maintenance of a healthy intestinal barrier; dysbiosis of intestinal microbial communities has emerged as a likely contributor to diseases that arise at the level of the mucosa. Intraepithelial lymphocytes (IELs) are positioned within the epithelial barrier, and in the small intestine they function to maintain epithelial homeostasis. We hypothesized that colon IELs promote epithelial barrier function through the expression of cytokines in response to interactions with commensal bacteria. Profiling of bacterial 16S ribosomal RNA revealed that candidate bacteria in the order Bacteroidales are sufficient to promote IEL presence in the colon that in turn produce interleukin-6 (IL-6) in a MyD88 (myeloid differentiation primary response 88)-dependent manner. IEL-derived IL-6 is functionally important in the maintenance of the epithelial barrier as IL-6(-/-) mice were noted to have increased paracellular permeability, decreased claudin-1 expression, and a thinner mucus gel layer, all of which were reversed by transfer of IL-6(+/+) IELs, leading to protection of mice in response to Citrobacter rodentium infection. Therefore, we conclude that microbiota provide a homeostatic role for epithelial barrier function through regulation of IEL-derived IL-6. Twit Text FOAVip Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28812548 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28812548 #FOAvip English Wikipedia <ref>{{Cite pmid|28812548 }}</ref> Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity #MMPMID28812548 Kuhn KA ; Schulz HM ; Regner EH ; Severs EL ; Hendrickson JD ; Mehta G ; Whitney AK ; Ir D ; Ohri N ; Robertson CE ; Frank DN ; Campbell EL ; Colgan SP Mucosal Immunol 2018[Mar]; 11 (2 ): 357-368 PMID28812548 show ga Interactions between the microbiota and distal gut are important for the maintenance of a healthy intestinal barrier; dysbiosis of intestinal microbial communities has emerged as a likely contributor to diseases that arise at the level of the mucosa. Intraepithelial lymphocytes (IELs) are positioned within the epithelial barrier, and in the small intestine they function to maintain epithelial homeostasis. We hypothesized that colon IELs promote epithelial barrier function through the expression of cytokines in response to interactions with commensal bacteria. Profiling of bacterial 16S ribosomal RNA revealed that candidate bacteria in the order Bacteroidales are sufficient to promote IEL presence in the colon that in turn produce interleukin-6 (IL-6) in a MyD88 (myeloid differentiation primary response 88)-dependent manner. IEL-derived IL-6 is functionally important in the maintenance of the epithelial barrier as IL-6(-/-) mice were noted to have increased paracellular permeability, decreased claudin-1 expression, and a thinner mucus gel layer, all of which were reversed by transfer of IL-6(+/+) IELs, leading to protection of mice in response to Citrobacter rodentium infection. Therefore, we conclude that microbiota provide a homeostatic role for epithelial barrier function through regulation of IEL-derived IL-6. |Animals [MESH] |Bacteroidaceae/*physiology [MESH] |Cell Membrane Permeability/genetics [MESH] |Citrobacter rodentium/*immunology [MESH] |Colon/*immunology [MESH] |Dysbiosis/*immunology [MESH] |Enterobacteriaceae Infections/*immunology [MESH] |Gastrointestinal Microbiome/*immunology [MESH] |Homeostasis [MESH] |Immunity, Innate [MESH] |Interleukin-6/genetics/*metabolism [MESH] |Intestinal Mucosa/*physiology [MESH] |Intraepithelial Lymphocytes/microbiology/*physiology [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Myeloid Differentiation Factor 88/metabolism [MESH] |RNA, Ribosomal, 16S/genetics [MESH]Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in th(epmc).pdf DeepDyve Pubget Overpricing