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10.1016/j.clim.2016.12.005 http://scihub22266oqcxt.onion/10.1016/j.clim.2016.12.005 C5815376!5815376 !28039018     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28039018 &cmd=llinks): Failed to open stream: HTTP request failed! 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Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus |pdf=|usr=}}{{28039018 }} gab.com Text Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus JO: Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28039018 #FOAvip Recent studies implicate innate immunity to systemic lupus erythematosus (SLE) pathogenesis. Toll-like receptor (TLR)8 is estrogen-regulated and binds viral ssRNA to stimulate innate immune responses, but recent work indicates that microRNA (miR)-21 within extracellular vesicles (EVs) can also trigger this receptor. Our objective was to examine TLR8 expression/activation to better understand sex-biased responses involving TLR8 in SLE. Our data identify an estrogen response element that promotes STAT1 expression and demonstrate STAT1-dependent transcriptional activation of TLR8 with estrogen stimulation. In lieu of viral ssRNA activation, we explored EV-encapsulated miR-21 as an endogenous ligand and observed induction of both TLR8 and cytokine expression in vitro. Moreover, extracellular miR detection was found predominantly within EVs. Thus, just as a cytokine or chemokine, EV-encapsulated miR-21 can act as an inflammatory signaling molecule, or miRokine, by virtue of being an endogenous ligand of TLR8. Collectively, our data elucidates a novel innate inflammatory pathway in SLE. Twit Text FOAVip Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus ????Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28039018 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28039018 #FOAvip English Wikipedia <ref>{{Cite pmid|28039018 }}</ref> Estrogen-regulated STAT1 activation promotes TLR8 expression to facilitate signaling via microRNA-21 in systemic lupus erythematosus #MMPMID28039018 Young NA ; Valiente GR ; Hampton JM ; Wu LC ; Burd CJ ; Willis WL ; Bruss M ; Steigelman H ; Gotsatsenko M ; Amici SA ; Severin M ; Claverie LM ; Guerau-de-Arellano M ; Lovett-Racke A ; Ardoin S ; Jarjour WN Clin Immunol 2017[Mar]; 176 (ä): 12-22 PMID28039018 show ga Recent studies implicate innate immunity to systemic lupus erythematosus (SLE) pathogenesis. Toll-like receptor (TLR)8 is estrogen-regulated and binds viral ssRNA to stimulate innate immune responses, but recent work indicates that microRNA (miR)-21 within extracellular vesicles (EVs) can also trigger this receptor. Our objective was to examine TLR8 expression/activation to better understand sex-biased responses involving TLR8 in SLE. Our data identify an estrogen response element that promotes STAT1 expression and demonstrate STAT1-dependent transcriptional activation of TLR8 with estrogen stimulation. In lieu of viral ssRNA activation, we explored EV-encapsulated miR-21 as an endogenous ligand and observed induction of both TLR8 and cytokine expression in vitro. Moreover, extracellular miR detection was found predominantly within EVs. Thus, just as a cytokine or chemokine, EV-encapsulated miR-21 can act as an inflammatory signaling molecule, or miRokine, by virtue of being an endogenous ligand of TLR8. Collectively, our data elucidates a novel innate inflammatory pathway in SLE. |Cell Line, Tumor [MESH] |Chemokines/metabolism [MESH] |Estrogens/*metabolism [MESH] |Humans [MESH] |Immunity, Innate/immunology [MESH] |Inflammation/immunology/metabolism [MESH] |Ligands [MESH] |Lupus Erythematosus, Systemic/immunology/*metabolism [MESH] |MCF-7 Cells [MESH] |MicroRNAs/*metabolism [MESH] |STAT1 Transcription Factor/*metabolism [MESH] |Signal Transduction/*physiology [MESH]Estrogen-regulated STAT1 activation promotes TLR8 expression to facili(epmc).pdf DeepDyve Pubget Overpricing