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10.1038/s41590-017-0005-y http://scihub22266oqcxt.onion/10.1038/s41590-017-0005-y C5815369!5815369!29180807     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2018 ; 19 (1): 53-62 Nephropedia Template TP {{tp|p=29180807|t=2018. Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity |pdf=|usr=}}{{29180807}} gab.com Text Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29180807 #FOAvip The sensor retinoic acid-inducible gene-I (RIG-I) detects double-stranded RNA derived from RNA viruses. Although RIG-I is also known to play a role in the antiviral response to DNA viruses, physiological RNA species recognized by RIG-I during DNA virus infection are largely unknown. Using next-generation RNA sequencing (RNAseq), we found that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bind to RIG-I during herpes simplex virus 1 (HSV-1) infection. HSV-1 infection induced relocalization of RNA5SP141 from the nucleus to the cytoplasm, and virus-induced shutoff of host protein synthesis downregulated RNA5SP141-interacting proteins, thereby allowing RNA5SP141 to bind RIG-I and induce type I interferon. Silencing of RNA5SP141 strongly dampened the antiviral response to HSV-1 and the related Epstein-Barr virus (EBV) as well as influenza A virus (IAV). Our findings reveal that antiviral immunity can be triggered by host RNAs that are unshielded following viral depletion of their respective binding proteins. Twit Text FOAVip Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29180807 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29180807 #FOAvip English Wikipedia <ref>{{Cite pmid|29180807}}</ref> Viral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG-I mediated immunity #MMPMID29180807 Chiang JJ; Sparrer KM; van Gent M; Lässig C; Huang T; Osterrieder N; Hopfner KP; Gack MU Nat Immunol 2018[Jan]; 19 (1): 53-62 PMID29180807show ga The sensor retinoic acid-inducible gene-I (RIG-I) detects double-stranded RNA derived from RNA viruses. Although RIG-I is also known to play a role in the antiviral response to DNA viruses, physiological RNA species recognized by RIG-I during DNA virus infection are largely unknown. Using next-generation RNA sequencing (RNAseq), we found that host-derived RNAs, most prominently 5S ribosomal RNA pseudogene 141 (RNA5SP141), bind to RIG-I during herpes simplex virus 1 (HSV-1) infection. HSV-1 infection induced relocalization of RNA5SP141 from the nucleus to the cytoplasm, and virus-induced shutoff of host protein synthesis downregulated RNA5SP141-interacting proteins, thereby allowing RNA5SP141 to bind RIG-I and induce type I interferon. Silencing of RNA5SP141 strongly dampened the antiviral response to HSV-1 and the related Epstein-Barr virus (EBV) as well as influenza A virus (IAV). Our findings reveal that antiviral immunity can be triggered by host RNAs that are unshielded following viral depletion of their respective binding proteins. äViral unmasking of cellular 5S rRNA pseudogene transcripts induces RIG(epmc).pdf DeepDyve Pubget Overpricing