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Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Eur+Endocrinol 2016 ; 12 (1): 44-6 Nephropedia Template TP
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New Developments in the Treatment of Neuroendocrine Tumours ? RADIANT-4, NETTER-1 and Telotristat Etiprate #MMPMID29632589
Sbardella E; Grossman A
Eur Endocrinol 2016[Mar]; 12 (1): 44-6 PMID29632589show ga
Neuroendocrine tumours (NETs) are a heterogeneous group of neoplasms whose incidence has increased significantly in recent years, and whose optimal management remains controversial. We report the latest innovations in their management, in particular the results of three trials concerning the use of the mammalian target of rapamycin (mTOR) inhibitor, everolimus, in non-functional NETs of lung/ gastrointestinal (GI) origin, the first randomised trial of radiolabelled 177Lu-DOTATATE in patients with mid-gut NETs, and the use of the 5-HT synthesis inhibitor, telotristat etiprate, in patients with the carcinoid syndrome.