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2016 ; 12
(1
): 44-46
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New Developments in the Treatment of Neuroendocrine Tumours - RADIANT-4, NETTER-1
and Telotristat Etiprate
#MMPMID29632589
Sbardella E
; Grossman A
Eur Endocrinol
2016[Mar]; 12
(1
): 44-46
PMID29632589
show ga
Neuroendocrine tumours (NETs) are a heterogeneous group of neoplasms whose
incidence has increased significantly in recent years, and whose optimal
management remains controversial. We report the latest innovations in their
management, in particular the results of three trials concerning the use of the
mammalian target of rapamycin (mTOR) inhibitor, everolimus, in non-functional
NETs of lung/ gastrointestinal (GI) origin, the first randomised trial of
radiolabelled (177)Lu-DOTATATE in patients with mid-gut NETs, and the use of the
5-HT synthesis inhibitor, telotristat etiprate, in patients with the carcinoid
syndrome.