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10.17925/EE.2016.12.01.12 http://scihub22266oqcxt.onion/10.17925/EE.2016.12.01.12 C5813452!5813452!29632581     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+Endocrinol 2016 ; 12 (1): 12-7 Nephropedia Template TP {{tp|p=29632581|t=2016. Recombinant Human Insulins ? Clinical Efficacy and Safety in Diabetes Therapy |pdf=|usr=}}{{29632581}} gab.com Text Recombinant Human Insulins Clinical Efficacy and Safety in Diabetes Therapy JO: Eur Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=29632581 #FOAvip Insulin replacement therapy is the standard of care for patients with type 1 and advanced type 2 diabetes mellitus. Porcine and bovine pancreatic tissue was the source of the hormone for many years, followed by semisynthetic human insulin obtained by modification of animal insulin. With the development of recombinant DNA technology, recombinant (biosynthetic) human insulin became available in large amounts by biosynthesis in microorganisms (Escherichia coli, yeast) providing reliable supplies of the hormone worldwide at affordable costs. The purity and pharmaceutical quality of recombinant human insulin was demonstrated to be superior to animal and semisynthetic insulin and patients with diabetes could be safely and effectively transferred from animal or semisynthetic human insulin to recombinant human insulin with no change expected in insulin dose. The decision for change remains a clinical objective, follow-up after any change of insulin product is recommended to confirm clinical efficacy. This review provides a summary and retrospective assessment of early clinical studies with recombinant insulins (Insuman®, Humulin®, Novolin®). Twit Text FOAVip Recombinant Human Insulins Clinical Efficacy and Safety in Diabetes Therapy ????Eur Endocrinol http://www.kidney.de/pget.php?&tw=1&pmid=29632581 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29632581 #FOAvip English Wikipedia <ref>{{Cite pmid|29632581}}</ref> Recombinant Human Insulins ? Clinical Efficacy and Safety in Diabetes Therapy #MMPMID29632581 Landgraf W; Sandow J Eur Endocrinol 2016[Mar]; 12 (1): 12-7 PMID29632581show ga Insulin replacement therapy is the standard of care for patients with type 1 and advanced type 2 diabetes mellitus. Porcine and bovine pancreatic tissue was the source of the hormone for many years, followed by semisynthetic human insulin obtained by modification of animal insulin. With the development of recombinant DNA technology, recombinant (biosynthetic) human insulin became available in large amounts by biosynthesis in microorganisms (Escherichia coli, yeast) providing reliable supplies of the hormone worldwide at affordable costs. The purity and pharmaceutical quality of recombinant human insulin was demonstrated to be superior to animal and semisynthetic insulin and patients with diabetes could be safely and effectively transferred from animal or semisynthetic human insulin to recombinant human insulin with no change expected in insulin dose. The decision for change remains a clinical objective, follow-up after any change of insulin product is recommended to confirm clinical efficacy. This review provides a summary and retrospective assessment of early clinical studies with recombinant insulins (Insuman®, Humulin®, Novolin®). äRecombinant Human Insulins ? Clinical Efficacy and Safety in Diabetes (epmc).pdf DeepDyve Pubget Overpricing