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10.1038/s41551-017-0153-2 http://scihub22266oqcxt.onion/10.1038/s41551-017-0153-2 C5809134!5809134!29450107     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Biomed+Eng 2017 ; 1 (11): 902-13 Nephropedia Template TP {{tp|p=29450107|t=2017. Macrogenomic engineering via modulation of the scaling of chromatin packing density |pdf=|usr=}}{{29450107}} gab.com Text Macrogenomic engineering via modulation of the scaling of chromatin packing density JO: Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=29450107 #FOAvip Many human diseases result from the dysregulation of the complex interactions between tens to thousands of genes. However, approaches for the transcriptional modulation of many genes simultaneously in a predictive manner are lacking. Here, through the combination of simulations, systems modelling and in?vitro experiments, we provide a physical regulatory framework based on chromatin packing-density heterogeneity for modulating the genomic information space. Because transcriptional interactions are essentially chemical reactions, they depend largely on the local physical nanoenvironment. We show that the regulation of the chromatin nanoenvironment allows for the predictable modulation of global patterns in gene expression. In particular, we show that the rational modulation of chromatin density fluctuations can lead to a decrease in global transcriptional activity and intercellular transcriptional heterogeneity in cancer cells during chemotherapeutic responses to achieve near-complete cancer cell killing in?vitro. Our findings represent a ?macrogenomic engineering? approach to modulating the physical structure of chromatin for whole-scale transcriptional modulation. Twit Text FOAVip Macrogenomic engineering via modulation of the scaling of chromatin packing density ????Nat Biomed Eng http://www.kidney.de/pget.php?&tw=1&pmid=29450107 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29450107 #FOAvip English Wikipedia <ref>{{Cite pmid|29450107}}</ref> Macrogenomic engineering via modulation of the scaling of chromatin packing density #MMPMID29450107 Almassalha LM; Bauer GM; Wu W; Cherkezyan L; Zhang D; Kendra A; Gladstein S; Chandler JE; VanDerway D; Seagle BLL; Ugolkov A; Billadeau DD; O?Halloran TV; Mazar AP; Roy HK; Szleifer I; Shahabi S; Backman V Nat Biomed Eng 2017[Nov]; 1 (11): 902-13 PMID29450107show ga Many human diseases result from the dysregulation of the complex interactions between tens to thousands of genes. However, approaches for the transcriptional modulation of many genes simultaneously in a predictive manner are lacking. Here, through the combination of simulations, systems modelling and in?vitro experiments, we provide a physical regulatory framework based on chromatin packing-density heterogeneity for modulating the genomic information space. Because transcriptional interactions are essentially chemical reactions, they depend largely on the local physical nanoenvironment. We show that the regulation of the chromatin nanoenvironment allows for the predictable modulation of global patterns in gene expression. In particular, we show that the rational modulation of chromatin density fluctuations can lead to a decrease in global transcriptional activity and intercellular transcriptional heterogeneity in cancer cells during chemotherapeutic responses to achieve near-complete cancer cell killing in?vitro. Our findings represent a ?macrogenomic engineering? approach to modulating the physical structure of chromatin for whole-scale transcriptional modulation. äMacrogenomic engineering via modulation of the scaling of chromatin pa(epmc).pdf DeepDyve Pubget Overpricing