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10.1038/ng.3958 http://scihub22266oqcxt.onion/10.1038/ng.3958 C5803080!5803080 !28945250     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28945250 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Genet 2017 ; 49 (11 ): 1613-1623 Nephropedia Template TP {{tp|p=28945250 |t=2017. SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters |pdf=|usr=}}{{28945250 }} gab.com Text SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters JO: Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=28945250 #FOAvip Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) complexes contribute to more than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor, an aggressive pediatric cancer characterized by biallelic inactivation of the core BAF complex subunit SMARCB1 (BAF47). However, the mechanism by which this alteration contributes to tumorigenesis remains poorly understood. We find that BAF47 loss destabilizes BAF complexes on chromatin, absent significant changes in complex assembly or integrity. Rescue of BAF47 in BAF47-deficient sarcoma cell lines results in increased genome-wide BAF complex occupancy, facilitating widespread enhancer activation and opposition of Polycomb-mediated repression at bivalent promoters. We demonstrate differential regulation by two distinct mSWI/SNF assemblies, BAF and PBAF complexes, enhancers and promoters, respectively, suggesting that each complex has distinct functions that are perturbed upon BAF47 loss. Our results demonstrate collaborative mechanisms of mSWI/SNF-mediated gene activation, identifying functions that are co-opted or abated to drive human cancers and developmental disorders. Twit Text FOAVip SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters ????Nat Genet http://www.kidney.de/pget.php?&tw=1&pmid=28945250 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28945250 #FOAvip English Wikipedia <ref>{{Cite pmid|28945250 }}</ref> SMARCB1 is required for widespread BAF complex-mediated activation of enhancers and bivalent promoters #MMPMID28945250 Nakayama RT ; Pulice JL ; Valencia AM ; McBride MJ ; McKenzie ZM ; Gillespie MA ; Ku WL ; Teng M ; Cui K ; Williams RT ; Cassel SH ; Qing H ; Widmer CJ ; Demetri GD ; Irizarry RA ; Zhao K ; Ranish JA ; Kadoch C Nat Genet 2017[Nov]; 49 (11 ): 1613-1623 PMID28945250 show ga Perturbations to mammalian SWI/SNF (mSWI/SNF or BAF) complexes contribute to more than 20% of human cancers, with driving roles first identified in malignant rhabdoid tumor, an aggressive pediatric cancer characterized by biallelic inactivation of the core BAF complex subunit SMARCB1 (BAF47). However, the mechanism by which this alteration contributes to tumorigenesis remains poorly understood. We find that BAF47 loss destabilizes BAF complexes on chromatin, absent significant changes in complex assembly or integrity. Rescue of BAF47 in BAF47-deficient sarcoma cell lines results in increased genome-wide BAF complex occupancy, facilitating widespread enhancer activation and opposition of Polycomb-mediated repression at bivalent promoters. We demonstrate differential regulation by two distinct mSWI/SNF assemblies, BAF and PBAF complexes, enhancers and promoters, respectively, suggesting that each complex has distinct functions that are perturbed upon BAF47 loss. Our results demonstrate collaborative mechanisms of mSWI/SNF-mediated gene activation, identifying functions that are co-opted or abated to drive human cancers and developmental disorders. |*Gene Expression Regulation, Neoplastic [MESH] |Carcinogenesis/*genetics/metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Chromatin Assembly and Disassembly [MESH] |Chromatin/chemistry/metabolism [MESH] |Chromosomal Proteins, Non-Histone/*genetics/metabolism [MESH] |Enhancer Elements, Genetic [MESH] |Genetic Complementation Test [MESH] |Humans [MESH] |Polycomb-Group Proteins/genetics/metabolism [MESH] |Promoter Regions, Genetic [MESH] |Rhabdoid Tumor/*genetics/metabolism/pathology [MESH] |SMARCB1 Protein/deficiency/*genetics [MESH] |Sarcoma/*genetics/metabolism/pathology [MESH]SMARCB1 is required for widespread BAF complex-mediated activation of (epmc).pdf DeepDyve Pubget Overpricing