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10.1073/pnas.1718009115 http://scihub22266oqcxt.onion/10.1073/pnas.1718009115 C5798374!5798374!29339479     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (5): E992-E1001 Nephropedia Template TP {{tp|p=29339479|t=2018. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice |pdf=|usr=}}{{29339479}} gab.com Text HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339479 #FOAvip Previous work showed that primary tumors instigate systemic macroenvironmental changes supporting cancer progression and metastasis. Here, we show that activation of HIF signaling in osteoblast-lineage cells also generates systemic changes promoting breast cancer growth and dissemination in bones and outside the skeleton. Our results indicate that loss of bone homeostasis through alterations of the bone anabolism could affect breast cancer progression and present the skeleton as an important organ of the tumor macroenvironment. They also suggest that targeting the bone microenvironment could limit systemic tumor growth and dissemination in breast cancer. Twit Text FOAVip HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29339479 #FOAvip English Wikipedia <ref>{{Cite pmid|29339479}}</ref> HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice #MMPMID29339479 Devignes CS; Aslan Y; Brenot A; Devillers A; Schepers K; Fabre S; Chou J; Casbon AJ; Werb Z; Provot S Proc Natl Acad Sci U S A 2018[Jan]; 115 (5): E992-E1001 PMID29339479show ga Previous work showed that primary tumors instigate systemic macroenvironmental changes supporting cancer progression and metastasis. Here, we show that activation of HIF signaling in osteoblast-lineage cells also generates systemic changes promoting breast cancer growth and dissemination in bones and outside the skeleton. Our results indicate that loss of bone homeostasis through alterations of the bone anabolism could affect breast cancer progression and present the skeleton as an important organ of the tumor macroenvironment. They also suggest that targeting the bone microenvironment could limit systemic tumor growth and dissemination in breast cancer. äHIF signaling in osteoblast-lineage cells promotes systemic breast can(epmc).pdf DeepDyve Pubget Overpricing