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10.1073/pnas.1718009115 http://scihub22266oqcxt.onion/10.1073/pnas.1718009115 C5798374!5798374 !29339479     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29339479 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (5 ): E992-E1001 Nephropedia Template TP {{tp|p=29339479 |t=2018. HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice |pdf=|usr=}}{{29339479 }} gab.com Text HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339479 #FOAvip Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1? in osteoblasts are essential to maintain skeletal homeostasis. However, the role of osteoblast-specific HIF signaling in cancer metastasis is unknown. Here, we show that osteoprogenitor cells (OPCs) are located in hypoxic niches in the bone marrow and that activation of HIF signaling in these cells increases bone mass and favors breast cancer metastasis to bone locally. Remarkably, HIF signaling in osteoblast-lineage cells also promotes breast cancer growth and dissemination remotely, in the lungs and in other tissues distant from bones. Mechanistically, we found that activation of HIF signaling in OPCs increases blood levels of the chemokine C-X-C motif ligand 12 (CXCL12), which leads to a systemic increase of breast cancer cell proliferation and dissemination through direct activation of the CXCR4 receptor. Hence, our data reveal a previously unrecognized role of the hypoxic osteogenic niche in promoting tumorigenesis beyond the local bone microenvironment. They also support the concept that the skeleton is an important regulator of the systemic tumor environment. Twit Text FOAVip HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339479 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29339479 #FOAvip English Wikipedia <ref>{{Cite pmid|29339479 }}</ref> HIF signaling in osteoblast-lineage cells promotes systemic breast cancer growth and metastasis in mice #MMPMID29339479 Devignes CS ; Aslan Y ; Brenot A ; Devillers A ; Schepers K ; Fabre S ; Chou J ; Casbon AJ ; Werb Z ; Provot S Proc Natl Acad Sci U S A 2018[Jan]; 115 (5 ): E992-E1001 PMID29339479 show ga Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1? in osteoblasts are essential to maintain skeletal homeostasis. However, the role of osteoblast-specific HIF signaling in cancer metastasis is unknown. Here, we show that osteoprogenitor cells (OPCs) are located in hypoxic niches in the bone marrow and that activation of HIF signaling in these cells increases bone mass and favors breast cancer metastasis to bone locally. Remarkably, HIF signaling in osteoblast-lineage cells also promotes breast cancer growth and dissemination remotely, in the lungs and in other tissues distant from bones. Mechanistically, we found that activation of HIF signaling in OPCs increases blood levels of the chemokine C-X-C motif ligand 12 (CXCL12), which leads to a systemic increase of breast cancer cell proliferation and dissemination through direct activation of the CXCR4 receptor. Hence, our data reveal a previously unrecognized role of the hypoxic osteogenic niche in promoting tumorigenesis beyond the local bone microenvironment. They also support the concept that the skeleton is an important regulator of the systemic tumor environment. |Alleles [MESH] |Amino Acid Motifs [MESH] |Animals [MESH] |Bone Neoplasms/secondary [MESH] |Bone and Bones/metabolism [MESH] |Cell Lineage [MESH] |Chemokine CXCL12/blood [MESH] |Disease Progression [MESH] |Female [MESH] |Green Fluorescent Proteins/metabolism [MESH] |Hypoxia [MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*genetics/*metabolism [MESH] |Ligands [MESH] |Mammary Neoplasms, Experimental/*genetics/*metabolism [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Neoplasm Metastasis [MESH] |Osteoblasts/*metabolism [MESH] |Osteoclasts/metabolism [MESH]HIF signaling in osteoblast-lineage cells promotes systemic breast can(epmc).pdf DeepDyve Pubget Overpricing