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10.1073/pnas.1717509115 http://scihub22266oqcxt.onion/10.1073/pnas.1717509115 C5798369!5798369!29339483     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (5): E876-85 Nephropedia Template TP {{tp|p=29339483|t=2018. HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome |pdf=|usr=}}{{29339483}} gab.com Text HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339483 #FOAvip The molecular basis of immunodeficiency?centromeric instability?facial anomalies (ICF) syndrome is poorly understood. ICF is caused by mutations in HELLS, CDCA7, or the DNA methyltransferase DNMT3b. While these mutations all cause DNA methylation defects, little is known about the molecular function of CDCA7. It has been speculated that HELLS, which belongs to the SNF2 family ATPase, facilitates DNA methylation by DNMT3b through nucleosome remodeling, but HELLS on its own fails to exhibit such an activity. Here, starting from a comparative proteomic analysis of chromatin proteins in frog egg extracts, we demonstrated that CDCA7 is required for HELLS to associate with chromatin and exert nucleosome remodeling activity. Our finding delineates the molecular pathway involving CDCA7, HELLS, and DNMT3b. Twit Text FOAVip HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339483 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29339483 #FOAvip English Wikipedia <ref>{{Cite pmid|29339483}}</ref> HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome #MMPMID29339483 Jenness C; Giunta S; Müller MM; Kimura H; Muir TW; Funabiki H Proc Natl Acad Sci U S A 2018[Jan]; 115 (5): E876-85 PMID29339483show ga The molecular basis of immunodeficiency?centromeric instability?facial anomalies (ICF) syndrome is poorly understood. ICF is caused by mutations in HELLS, CDCA7, or the DNA methyltransferase DNMT3b. While these mutations all cause DNA methylation defects, little is known about the molecular function of CDCA7. It has been speculated that HELLS, which belongs to the SNF2 family ATPase, facilitates DNA methylation by DNMT3b through nucleosome remodeling, but HELLS on its own fails to exhibit such an activity. Here, starting from a comparative proteomic analysis of chromatin proteins in frog egg extracts, we demonstrated that CDCA7 is required for HELLS to associate with chromatin and exert nucleosome remodeling activity. Our finding delineates the molecular pathway involving CDCA7, HELLS, and DNMT3b. äHELLS and CDCA7 comprise a bipartite nucleosome remodeling complex def(epmc).pdf DeepDyve Pubget Overpricing