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10.1073/pnas.1715531115 http://scihub22266oqcxt.onion/10.1073/pnas.1715531115 C5798355!5798355!29339519     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (5): 968-73 Nephropedia Template TP {{tp|p=29339519|t=2018. Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay |pdf=|usr=}}{{29339519}} gab.com Text Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339519 #FOAvip Short interspersed elements (SINEs) are retrotransposons that have accumulated in genomes through a ?copy-and-paste? mechanism. Once inserted, these sequences have the potential to gain novel functions, including regulating gene expression. Here, we demonstrate the unexpected finding that independently evolved SINEs have accumulated in the 3?-untranslated regions of orthologous human and mouse genes. We demonstrate that, in some cases, this has resulted in their regulating gene expression by Staufen-mediated mRNA decay (SMD) in human and mouse myoblasts. Thus, SINE-directed SMD has convergently evolved to regulate myoblast metabolism. This represents an example of the convergent evolution of posttranscriptional gene regulation using SINEs. Twit Text FOAVip Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339519 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29339519 #FOAvip English Wikipedia <ref>{{Cite pmid|29339519}}</ref> Evidence for convergent evolution of SINE-directed Staufen-mediated mRNA decay #MMPMID29339519 Lucas BA; Lavi E; Shiue L; Cho H; Katzman S; Miyoshi K; Siomi MC; Carmel L; Ares M; Maquat LE Proc Natl Acad Sci U S A 2018[Jan]; 115 (5): 968-73 PMID29339519show ga Short interspersed elements (SINEs) are retrotransposons that have accumulated in genomes through a ?copy-and-paste? mechanism. Once inserted, these sequences have the potential to gain novel functions, including regulating gene expression. Here, we demonstrate the unexpected finding that independently evolved SINEs have accumulated in the 3?-untranslated regions of orthologous human and mouse genes. We demonstrate that, in some cases, this has resulted in their regulating gene expression by Staufen-mediated mRNA decay (SMD) in human and mouse myoblasts. Thus, SINE-directed SMD has convergently evolved to regulate myoblast metabolism. This represents an example of the convergent evolution of posttranscriptional gene regulation using SINEs. äEvidence for convergent evolution of SINE-directed Staufen-mediated mR(epmc).pdf DeepDyve Pubget Overpricing