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10.1038/mi.2017.77 http://scihub22266oqcxt.onion/10.1038/mi.2017.77 C5797694!5797694!29067998     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mucosal+Immunol 2018 ; 11 (2): 523-35 Nephropedia Template TP {{tp|p=29067998|t=2018. Epithelial derived TGF-?1 acts as a pro-viral factor in the lung during influenza A infection |pdf=|usr=}}{{29067998}} gab.com Text Epithelial derived TGF- 1 acts as a pro-viral factor in the lung during influenza A infection JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29067998 #FOAvip Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate immune activation and consequent pathology. Epithelial cells play a vital role orchestrating pulmonary homeostasis and defense against pathogens. TGF-? regulates an array of immune responses- both inflammatory and regulatory, however its function is highly location and context dependent. We demonstrate that epithelial derived TGF-? acts as a pro-viral factor suppressing early immune responses during influenza A infection. Mice specifically lacking bronchial epithelial TGF-?1 (epTGF?KO) displayed marked protection from influenza induced weight loss, airway inflammation and pathology. However, protection from influenza induced pathology was not associated with a heightened lymphocytic immune response. In contrast, the kinetics of IFN? release into the airways was significantly enhanced in epTGF?KO mice compared to control mice, with elevated IFN? at day 1 in epTGF?KO compared to control mice. This induced a heighted anti-viral state resulting in impaired viral replication in epTGF?KO mice.Thus, epithelial derived TGF-? acts to suppress early IFN? responses leading to increased viral burden and pathology. This study demonstrates the importance of the local epithelial micro-environmental niche in shaping initial immune responses to viral infection and controlling host disease. Twit Text FOAVip Epithelial derived TGF- 1 acts as a pro-viral factor in the lung during influenza A infection ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29067998 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29067998 #FOAvip English Wikipedia <ref>{{Cite pmid|29067998}}</ref> Epithelial derived TGF-?1 acts as a pro-viral factor in the lung during influenza A infection #MMPMID29067998 Denney L; Branchett W; Gregory LG; Oliver RA; Lloyd CM Mucosal Immunol 2018[Mar]; 11 (2): 523-35 PMID29067998show ga Mucosal surfaces are under constant bombardment from potentially antigenic particles and so must maintain a balance between homeostasis and inappropriate immune activation and consequent pathology. Epithelial cells play a vital role orchestrating pulmonary homeostasis and defense against pathogens. TGF-? regulates an array of immune responses- both inflammatory and regulatory, however its function is highly location and context dependent. We demonstrate that epithelial derived TGF-? acts as a pro-viral factor suppressing early immune responses during influenza A infection. Mice specifically lacking bronchial epithelial TGF-?1 (epTGF?KO) displayed marked protection from influenza induced weight loss, airway inflammation and pathology. However, protection from influenza induced pathology was not associated with a heightened lymphocytic immune response. In contrast, the kinetics of IFN? release into the airways was significantly enhanced in epTGF?KO mice compared to control mice, with elevated IFN? at day 1 in epTGF?KO compared to control mice. This induced a heighted anti-viral state resulting in impaired viral replication in epTGF?KO mice.Thus, epithelial derived TGF-? acts to suppress early IFN? responses leading to increased viral burden and pathology. This study demonstrates the importance of the local epithelial micro-environmental niche in shaping initial immune responses to viral infection and controlling host disease. äEpithelial derived TGF-?1 acts as a pro-viral factor in the lung durin(epmc).pdf DeepDyve Pubget Overpricing