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10.1016/j.neuron.2017.06.030 http://scihub22266oqcxt.onion/10.1016/j.neuron.2017.06.030 C5796650!5796650!28683266     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Neuron 2017 ; 95 (1): 221-231.e4 Nephropedia Template TP {{tp|p=28683266|t=2017. Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy |pdf=|usr=}}{{28683266}} gab.com Text Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy JO: Neuron http://www.kidney.de/pget.php?&tw=1&pmid=28683266 #FOAvip Psychopathy is a personality disorder with strong links to criminal behavior. While research on psychopathy has focused largely on socio-affective dysfunction, recent data suggest that aberrant decision making may also play an important role. Yet, the circuit-level mechanisms underlying maladaptive decision making in psychopathy remain unclear. Here, we used a multi-modality functional imaging approach to identify these mechanisms in a population of adult male incarcerated offenders. Psychopathy was associated with stronger subjective value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice and with weaker intrinsic functional connectivity between NAcc and ventromedial prefrontal cortex (vmPFC). NAcc-vmPFC connectivity strength was negatively correlated with NAcc subjective value-related activity; however, this putative regulatory pattern was abolished as psychopathy severity increased. Finally, weaker cortico-striatal regulation predicted more frequent criminal convictions. These data suggest that cortico-striatal circuit dysregulation drives maladaptive decision making in psychopathy, supporting the notion that reward system dysfunction comprises an important neurobiological risk factor. Twit Text FOAVip Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy ????Neuron http://www.kidney.de/pget.php?&tw=1&pmid=28683266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28683266 #FOAvip English Wikipedia <ref>{{Cite pmid|28683266}}</ref> Disrupted Prefrontal Regulation of Striatal Subjective Value Signals in Psychopathy #MMPMID28683266 Hosking JG; Kastman EK; Dorfman HM; Samanez-Larkin GR; Baskin-Sommers A; Kiehl KA; Newman JP; Buckholtz JW Neuron 2017[Jul]; 95 (1): 221-231.e4 PMID28683266show ga Psychopathy is a personality disorder with strong links to criminal behavior. While research on psychopathy has focused largely on socio-affective dysfunction, recent data suggest that aberrant decision making may also play an important role. Yet, the circuit-level mechanisms underlying maladaptive decision making in psychopathy remain unclear. Here, we used a multi-modality functional imaging approach to identify these mechanisms in a population of adult male incarcerated offenders. Psychopathy was associated with stronger subjective value-related activity within the nucleus accumbens (NAcc) during inter-temporal choice and with weaker intrinsic functional connectivity between NAcc and ventromedial prefrontal cortex (vmPFC). NAcc-vmPFC connectivity strength was negatively correlated with NAcc subjective value-related activity; however, this putative regulatory pattern was abolished as psychopathy severity increased. Finally, weaker cortico-striatal regulation predicted more frequent criminal convictions. These data suggest that cortico-striatal circuit dysregulation drives maladaptive decision making in psychopathy, supporting the notion that reward system dysfunction comprises an important neurobiological risk factor. äDisrupted Prefrontal Regulation of Striatal Subjective Value Signals i(epmc).pdf DeepDyve Pubget Overpricing