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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Anal+Biochem
2018 ; 552
(ä): 50-59
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Mitochondrial membrane potential
#MMPMID28711444
Zorova LD
; Popkov VA
; Plotnikov EY
; Silachev DN
; Pevzner IB
; Jankauskas SS
; Babenko VA
; Zorov SD
; Balakireva AV
; Juhaszova M
; Sollott SJ
; Zorov DB
Anal Biochem
2018[Jul]; 552
(ä): 50-59
PMID28711444
show ga
The mitochondrial membrane potential (??m) generated by proton pumps (Complexes
I, III and IV) is an essential component in the process of energy storage during
oxidative phosphorylation. Together with the proton gradient (?pH), ??m forms the
transmembrane potential of hydrogen ions which is harnessed to make ATP. The
levels of ??m and ATP in the cell are kept relatively stable although there are
limited fluctuations of both these factors that can occur reflecting normal
physiological activity. However, sustained changes in both factors may be
deleterious. A long-lasting drop or rise of ??m vs normal levels may induce
unwanted loss of cell viability and be a cause of various pathologies. Among
other factors, ??m plays a key role in mitochondrial homeostasis through
selective elimination of dysfunctional mitochondria. It is also a driving force
for transport of ions (other than H(+)) and proteins which are necessary for
healthy mitochondrial functioning. We propose additional potential mechanisms for
which ??m is essential for maintenance of cellular health and viability and
provide recommendations how to accurately measure ??m in a cell and discuss
potential sources of artifacts.
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