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10.1038/nsmb.3481 http://scihub22266oqcxt.onion/10.1038/nsmb.3481 C5791885!5791885!28991266     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Struct+Mol+Biol 2017 ; 24 (11): 902-10 Nephropedia Template TP {{tp|p=28991266|t=2017. MacroH2A1 1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption |pdf=|usr=}}{{28991266}} gab.com Text MacroH2A1 1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption JO: Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28991266 #FOAvip Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A.1.1 contains a macrodomain able to bind NAD+ derived metabolites. Here, we report that macroH2A.1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing. Importantly, myotubes lacking macroH2A.1.1 display a defect in mitochondrial respiratory capacity. We find that the metabolite-interacting macrodomain is essential for sustaining optimal mitochondrial function, but dispensable for gene regulation. Through direct binding, macroH2A.1.1 inhibits basal poly-ADP ribose polymerase 1 activity and thus reduces nuclear NAD+ consumption. Consequentially, accumulation of the NAD+ precursor NMN allows the maintenance of mitochondrial NAD+ pools critical for respiration.Our data indicate that macroH2A.1.1-containing chromatin regulates mitochondrial respiration by limiting nuclear NAD+ consumption and establishing a buffer of NAD+ precursors in differentiated cells. Twit Text FOAVip MacroH2A1 1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption ????Nat Struct Mol Biol http://www.kidney.de/pget.php?&tw=1&pmid=28991266 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28991266 #FOAvip English Wikipedia <ref>{{Cite pmid|28991266}}</ref> MacroH2A1 1 regulates mitochondrial respiration by limiting nuclear NAD+ consumption #MMPMID28991266 Posavec Marjanovi? M; Hurtado-Bagès S; Lassi M; Valero V; Malinverni R; Delage H; Navarro M; Corujo D; Guberovic I; Douet J; Gama-Perez P; Garcia-Roves PM; Ahel I; Ladurner AG; Yanes O; Bouvet P; Suelves M; Teperino R; Pospisilik JA; Buschbeck M Nat Struct Mol Biol 2017[Nov]; 24 (11): 902-10 PMID28991266show ga Histone variants are structural components of eukaryotic chromatin that can replace replication-coupled histones in the nucleosome. The histone variant macroH2A.1.1 contains a macrodomain able to bind NAD+ derived metabolites. Here, we report that macroH2A.1.1 is rapidly induced during myogenic differentiation through a switch in alternative splicing. Importantly, myotubes lacking macroH2A.1.1 display a defect in mitochondrial respiratory capacity. We find that the metabolite-interacting macrodomain is essential for sustaining optimal mitochondrial function, but dispensable for gene regulation. Through direct binding, macroH2A.1.1 inhibits basal poly-ADP ribose polymerase 1 activity and thus reduces nuclear NAD+ consumption. Consequentially, accumulation of the NAD+ precursor NMN allows the maintenance of mitochondrial NAD+ pools critical for respiration.Our data indicate that macroH2A.1.1-containing chromatin regulates mitochondrial respiration by limiting nuclear NAD+ consumption and establishing a buffer of NAD+ precursors in differentiated cells. äMacroH2A1 1 regulates mitochondrial respiration by limiting nuclear NA(epmc).pdf DeepDyve Pubget Overpricing