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10.1038/ncb3610 http://scihub22266oqcxt.onion/10.1038/ncb3610 C5790113!5790113!28892079     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28892079&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Cell+Biol 2017 ; 19 (10): 1214-25 Nephropedia Template TP {{tp|p=28892079|t=2017. Retriever, a multiprotein complex for retromer-independent endosomal cargo recycling |pdf=|usr=}}{{28892079}} gab.com Text Retriever, a multiprotein complex for retromer-independent endosomal cargo recycling JO: Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28892079 #FOAvip Following endocytosis and entry into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are alternatively retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multi-protein complex which orchestrates cargo retrieval and recycling and importantly, is biochemically and functionally distinct to the established retromer pathway. Composed of a heterotrimer of DSCR3, C16orf62 and VPS29, and bearing striking similarity with retromer, we have called this complex ?retriever?. We establish that retriever associates with the cargo adaptor sorting nexin 17 (SNX17) and couples to the CCC and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of ?5?1-integrin. Through quantitative proteomic analysis we identify over 120 cell surface proteins, including numerous integrins, signalling receptors and solute transporters, which require SNX17-retriever to maintain their surface levels. Our identification of retriever establishes a major new endosomal retrieval and recycling pathway. Twit Text FOAVip Retriever, a multiprotein complex for retromer-independent endosomal cargo recycling ????Nat Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28892079 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28892079 #FOAvip English Wikipedia <ref>{{Cite pmid|28892079}}</ref> Retriever, a multiprotein complex for retromer-independent endosomal cargo recycling #MMPMID28892079 McNally KE; Faulkner R; Steinberg F; Gallon M; Ghai R; Pim D; Langton P; Pearson N; Danson CM; Nägele H; Morris LM; Singla A; Overlee BL; Heesom KJ; Sessions R; Banks L; Collins BM; Berger I; Billadeau DD; Burstein E; Cullen PJ Nat Cell Biol 2017[Oct]; 19 (10): 1214-25 PMID28892079show ga Following endocytosis and entry into the endosomal network, integral membrane proteins undergo sorting for lysosomal degradation or are alternatively retrieved and recycled back to the cell surface. Here we describe the discovery of an ancient and conserved multi-protein complex which orchestrates cargo retrieval and recycling and importantly, is biochemically and functionally distinct to the established retromer pathway. Composed of a heterotrimer of DSCR3, C16orf62 and VPS29, and bearing striking similarity with retromer, we have called this complex ?retriever?. We establish that retriever associates with the cargo adaptor sorting nexin 17 (SNX17) and couples to the CCC and WASH complexes to prevent lysosomal degradation and promote cell surface recycling of ?5?1-integrin. Through quantitative proteomic analysis we identify over 120 cell surface proteins, including numerous integrins, signalling receptors and solute transporters, which require SNX17-retriever to maintain their surface levels. Our identification of retriever establishes a major new endosomal retrieval and recycling pathway. äRetriever, a multiprotein complex for retromer-independent endosomal c(epmc).pdf DeepDyve Pubget Overpricing