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10.1073/pnas.1718653115 http://scihub22266oqcxt.onion/10.1073/pnas.1718653115 C5789953!5789953!29339506     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (4): 647-55 Nephropedia Template TP {{tp|p=29339506|t=2018. Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle |pdf=|usr=}}{{29339506}} gab.com Text Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339506 #FOAvip The LipB?LipA and lipoyl-relay pathways seem restricted to gram-negative and gram-positive bacteria, respectively. Braakman and Smith have persuasively argued that the lipoyl-relay pathway involving transfer of lipoic acid from lipoylated GcvH is the primordial pathway and that the LipB?LipA pathway arose later. The chemically challenging nature of lipoyl transfer strengthens this argument. Given the roughly 3 billion years since the two groups of bacteria diverged, it is unexpected and puzzling that the lipoyl transfer properties of many GcvHs?those from eukaryotes and bacteria, including Escherichia coli, and the deep-branching hyperthermophilic chemoautotrophic bacterium, Aquifex aeolicus?have lipoyl-relay activity in Bacillus subtilis. This provides a remarkable case in which a protein ?moonlighting? function is found throughout evolution without selection for the function. Twit Text FOAVip Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29339506 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29339506 #FOAvip English Wikipedia <ref>{{Cite pmid|29339506}}</ref> Development and retention of a primordial moonlighting pathway of protein modification in the absence of selection presents a puzzle #MMPMID29339506 Cao X; Hong Y; Zhu L; Hu Y; Cronan JE Proc Natl Acad Sci U S A 2018[Jan]; 115 (4): 647-55 PMID29339506show ga The LipB?LipA and lipoyl-relay pathways seem restricted to gram-negative and gram-positive bacteria, respectively. Braakman and Smith have persuasively argued that the lipoyl-relay pathway involving transfer of lipoic acid from lipoylated GcvH is the primordial pathway and that the LipB?LipA pathway arose later. The chemically challenging nature of lipoyl transfer strengthens this argument. Given the roughly 3 billion years since the two groups of bacteria diverged, it is unexpected and puzzling that the lipoyl transfer properties of many GcvHs?those from eukaryotes and bacteria, including Escherichia coli, and the deep-branching hyperthermophilic chemoautotrophic bacterium, Aquifex aeolicus?have lipoyl-relay activity in Bacillus subtilis. This provides a remarkable case in which a protein ?moonlighting? function is found throughout evolution without selection for the function. äDevelopment and retention of a primordial moonlighting pathway of prot(epmc).pdf DeepDyve Pubget Overpricing