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10.1073/pnas.1717507115 http://scihub22266oqcxt.onion/10.1073/pnas.1717507115 C5789941!5789941!29311303     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (4): 810-5 Nephropedia Template TP {{tp|p=29311303|t=2018. Pyruvate induces torpor in obese mice |pdf=|usr=}}{{29311303}} gab.com Text Pyruvate induces torpor in obese mice JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29311303 #FOAvip Mice can reduce their body temperature and metabolic rate and enter torpor when they are subjected to cold, calorie deprivation, or administration of some metabolic inhibitors. Here we show that administration of pyruvate, a key metabolic intermediate and substrate for gluconeogenesis, induces torpor in obese mice, resulting in marked hypothermia, decreased activity, and decreased metabolic rate. This is dependent on adenosine signaling and on changes in key brain metabolites, including GABA. Lean mice are protected from pyruvate-induced torpor by activating their brown adipose tissue. Understanding this pathway can help provide new approaches for inducing a hypometabolic state in mammals, which could be beneficial in states of food deprivation or ischemia?reperfusion injury and for organ preservation in surgical situations. Twit Text FOAVip Pyruvate induces torpor in obese mice ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29311303 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29311303 #FOAvip English Wikipedia <ref>{{Cite pmid|29311303}}</ref> Pyruvate induces torpor in obese mice #MMPMID29311303 Soto M; Orliaguet L; Reyzer ML; Manier ML; Caprioli RM; Kahn CR Proc Natl Acad Sci U S A 2018[Jan]; 115 (4): 810-5 PMID29311303show ga Mice can reduce their body temperature and metabolic rate and enter torpor when they are subjected to cold, calorie deprivation, or administration of some metabolic inhibitors. Here we show that administration of pyruvate, a key metabolic intermediate and substrate for gluconeogenesis, induces torpor in obese mice, resulting in marked hypothermia, decreased activity, and decreased metabolic rate. This is dependent on adenosine signaling and on changes in key brain metabolites, including GABA. Lean mice are protected from pyruvate-induced torpor by activating their brown adipose tissue. Understanding this pathway can help provide new approaches for inducing a hypometabolic state in mammals, which could be beneficial in states of food deprivation or ischemia?reperfusion injury and for organ preservation in surgical situations. äPyruvate induces torpor in obese mice (epmc).pdf DeepDyve Pubget Overpricing