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10.1073/pnas.1709111115 http://scihub22266oqcxt.onion/10.1073/pnas.1709111115 C5789908!5789908!29305555     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29305555&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (4): E705-14 Nephropedia Template TP {{tp|p=29305555|t=2018. Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa |pdf=|usr=}}{{29305555}} gab.com Text Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29305555 #FOAvip We describe a unique role for the lymphoid extracellular matrix in maintaining systemic innate immunity. Our findings are based on studies of the genetic skin disorder recessive dystrophic epidermolysis bullosa in which affected individuals display dramatically increased bacterial colonization of skin and mucosa. We show that the increased colonization is a consequence of loss of the protein at fault?collagen VII?from the lymphoid extracellular matrix. Our study describes an intrinsic innate immune defect resulting from a genetic connective tissue disease. Hence, the data will have broad implications for deciphering the hitherto-underestimated regulatory role of the extracellular matrix in lymphoid organs and for the understanding of pathomechanisms in disorders of the extracellular matrix. Twit Text FOAVip Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29305555 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29305555 #FOAvip English Wikipedia <ref>{{Cite pmid|29305555}}</ref> Impaired lymphoid extracellular matrix impedes antibacterial immunity in epidermolysis bullosa #MMPMID29305555 Nyström A; Bornert O; Kühl T; Gretzmeier C; Thriene K; Dengjel J; Pfister-Wartha A; Kiritsi D; Bruckner-Tuderman L Proc Natl Acad Sci U S A 2018[Jan]; 115 (4): E705-14 PMID29305555show ga We describe a unique role for the lymphoid extracellular matrix in maintaining systemic innate immunity. Our findings are based on studies of the genetic skin disorder recessive dystrophic epidermolysis bullosa in which affected individuals display dramatically increased bacterial colonization of skin and mucosa. We show that the increased colonization is a consequence of loss of the protein at fault?collagen VII?from the lymphoid extracellular matrix. Our study describes an intrinsic innate immune defect resulting from a genetic connective tissue disease. Hence, the data will have broad implications for deciphering the hitherto-underestimated regulatory role of the extracellular matrix in lymphoid organs and for the understanding of pathomechanisms in disorders of the extracellular matrix. äImpaired lymphoid extracellular matrix impedes antibacterial immunity (epmc).pdf DeepDyve Pubget Overpricing