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10.1021/acs.accounts.6b00565 http://scihub22266oqcxt.onion/10.1021/acs.accounts.6b00565 C5786153!5786153!28945413     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Acc+Chem+Res 2017 ; 50 (3): 584-9 Nephropedia Template TP {{tp|p=28945413|t=2017. From Fuzzy to Function: The New Frontier of Protein?Protein Interactions |pdf=|usr=}}{{28945413}} gab.com Text From Fuzzy to Function: The New Frontier of Protein Protein Interactions JO: Acc Chem Res http://www.kidney.de/pget.php?&tw=1&pmid=28945413 #FOAvip Conformationally heterogenous or ?fuzzy? proteins have often been described as lacking specificity in binding and in function. The activation domains, for example, of transcriptional activators were labeled as negative noodles, with little structure or specificity. However, emerging data illustrates that the opposite is true: conformational heterogeneity enables context-specific function to emerge in response to changing cellular conditions and, furthermore, allows a single structural motif to be used in multiple settings. A further benefit is that conformational heterogeneity can be harnessed for the discovery of allosteric drug-like modulators, targeting critical pathways in protein homeostasis and transcription. Twit Text FOAVip From Fuzzy to Function: The New Frontier of Protein Protein Interactions ????Acc Chem Res http://www.kidney.de/pget.php?&tw=1&pmid=28945413 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28945413 #FOAvip English Wikipedia <ref>{{Cite pmid|28945413}}</ref> From Fuzzy to Function: The New Frontier of Protein?Protein Interactions #MMPMID28945413 Pricer R; Gestwicki JE; Mapp AK Acc Chem Res 2017[Mar]; 50 (3): 584-9 PMID28945413show ga Conformationally heterogenous or ?fuzzy? proteins have often been described as lacking specificity in binding and in function. The activation domains, for example, of transcriptional activators were labeled as negative noodles, with little structure or specificity. However, emerging data illustrates that the opposite is true: conformational heterogeneity enables context-specific function to emerge in response to changing cellular conditions and, furthermore, allows a single structural motif to be used in multiple settings. A further benefit is that conformational heterogeneity can be harnessed for the discovery of allosteric drug-like modulators, targeting critical pathways in protein homeostasis and transcription. äFrom Fuzzy to Function: The New Frontier of Protein?Protein Interactio(epmc).pdf DeepDyve Pubget Overpricing