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10.1080/15476286.2017.1341033 http://scihub22266oqcxt.onion/10.1080/15476286.2017.1341033 C5785221!5785221!28640667     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       RNA+Biol 2017 ; 14 (11): 1485-91 Nephropedia Template TP {{tp|p=28640667|t=2017. Restricting retrotransposons: ADAR1 is another guardian of the human genome |pdf=|usr=}}{{28640667}} gab.com Text Restricting retrotransposons: ADAR1 is another guardian of the human genome JO: RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=28640667 #FOAvip ADAR1 is an enzyme that belongs to the Adenosine Deaminases Acting on RNA (ADARs) family. These enzymes deaminate adenosines to inosines (RNA editing A-to-I) within double-stranded RNA regions in transcripts. Since inosines are recognized as guanosines by the cellular machinery, RNA editing mediated by ADARs can either lead to the formation of an altered protein (recoding) or affect different aspects of RNA metabolism.Recently, a proteomic analysis led to the identification of novel ADAR1-associated factors and found that a good fraction of them is shared with the Long Interspersed Element 1 (LINE-1 or L1) ribonucleoparticles (RNPs). This evidence suggested a possible role of ADAR1 in regulating the L1 life cycle. By taking advantage of the use of cell culture retrotransposition assays, a novel function of this deaminase as an inhibitor of L1 retrotransposition was demonstrated. These results pave the way toward a better comprehension of the mechanisms of restriction of retrotransposons. Twit Text FOAVip Restricting retrotransposons: ADAR1 is another guardian of the human genome ????RNA Biol http://www.kidney.de/pget.php?&tw=1&pmid=28640667 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28640667 #FOAvip English Wikipedia <ref>{{Cite pmid|28640667}}</ref> Restricting retrotransposons: ADAR1 is another guardian of the human genome #MMPMID28640667 Orecchini E; Frassinelli L; Michienzi A RNA Biol 2017[]; 14 (11): 1485-91 PMID28640667show ga ADAR1 is an enzyme that belongs to the Adenosine Deaminases Acting on RNA (ADARs) family. These enzymes deaminate adenosines to inosines (RNA editing A-to-I) within double-stranded RNA regions in transcripts. Since inosines are recognized as guanosines by the cellular machinery, RNA editing mediated by ADARs can either lead to the formation of an altered protein (recoding) or affect different aspects of RNA metabolism.Recently, a proteomic analysis led to the identification of novel ADAR1-associated factors and found that a good fraction of them is shared with the Long Interspersed Element 1 (LINE-1 or L1) ribonucleoparticles (RNPs). This evidence suggested a possible role of ADAR1 in regulating the L1 life cycle. By taking advantage of the use of cell culture retrotransposition assays, a novel function of this deaminase as an inhibitor of L1 retrotransposition was demonstrated. These results pave the way toward a better comprehension of the mechanisms of restriction of retrotransposons. äRestricting retrotransposons: ADAR1 is another guardian of the human g(epmc).pdf DeepDyve Pubget Overpricing