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10.1002/jcb.25948 http://scihub22266oqcxt.onion/10.1002/jcb.25948 C5783695!5783695!28230277     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Biochem 2017 ; 118 (9): 2516-27 Nephropedia Template TP {{tp|p=28230277|t=2017. Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma |pdf=|usr=}}{{28230277}} gab.com Text Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma JO: J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=28230277 #FOAvip Glioblastoma Multiforme (GBM) is a highly malignant primary brain cancer that is associated with abysmal prognosis. The median survival of GBM patients is ~15 months and there have not been any significant advance in therapies in over a decade, leaving treatment options limited. There is clearly an unmet need for GBM treatment. Immunotherapies are treatments based on usurping the power of the host?s immune system to recognize and eliminate cancer cells. They have recently proven to be a successful strategy for combating a variety of cancers. Of the various types of immunotherapies, checkpoint blockade approaches have thus far produced significant clinical responses in several cancers including melanoma, non small-cell lung cancer, renal cancer and prostate cancer. This review focuses on the biological rationale for using checkpoint blockade immunotherapeutic approaches in primary brain cancer and an up-to-date summary of current and ongoing checkpoint inhibitors-based clinical trials for malignant glioma. In addition, we expand on new concepts for further improving checkpoint blockade treatments, with a particular focus on the advantages of using genetically engineered mouse models for studies of immunotherapies in GBM. Twit Text FOAVip Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma ????J Cell Biochem http://www.kidney.de/pget.php?&tw=1&pmid=28230277 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28230277 #FOAvip English Wikipedia <ref>{{Cite pmid|28230277}}</ref> Immune Checkpoint Blockade Biology in Mouse Models of Glioblastoma #MMPMID28230277 Yeo AT; Charest A J Cell Biochem 2017[Sep]; 118 (9): 2516-27 PMID28230277show ga Glioblastoma Multiforme (GBM) is a highly malignant primary brain cancer that is associated with abysmal prognosis. The median survival of GBM patients is ~15 months and there have not been any significant advance in therapies in over a decade, leaving treatment options limited. There is clearly an unmet need for GBM treatment. Immunotherapies are treatments based on usurping the power of the host?s immune system to recognize and eliminate cancer cells. They have recently proven to be a successful strategy for combating a variety of cancers. Of the various types of immunotherapies, checkpoint blockade approaches have thus far produced significant clinical responses in several cancers including melanoma, non small-cell lung cancer, renal cancer and prostate cancer. This review focuses on the biological rationale for using checkpoint blockade immunotherapeutic approaches in primary brain cancer and an up-to-date summary of current and ongoing checkpoint inhibitors-based clinical trials for malignant glioma. In addition, we expand on new concepts for further improving checkpoint blockade treatments, with a particular focus on the advantages of using genetically engineered mouse models for studies of immunotherapies in GBM. äImmune Checkpoint Blockade Biology in Mouse Models of Glioblastoma (epmc).pdf DeepDyve Pubget Overpricing