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10.1073/pnas.1714670115 http://scihub22266oqcxt.onion/10.1073/pnas.1714670115 C5777051!5777051!29279371     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (2): 391-6 Nephropedia Template TP {{tp|p=29279371|t=2018. Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia |pdf=|usr=}}{{29279371}} gab.com Text Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29279371 #FOAvip Waste nitrogen is converted into urea by the healthy liver. Systemic ammonia is elevated in patients with inherited urea-cycle disorders or acute and chronic liver diseases. Hyperammonemia is a challenging medical condition that holds high risks of mortality and irreversible brain damage. Current treatments are often inadequate. Autophagy is a lysosomal recycling pathway that plays a major role in metabolism. Here, we found that liver autophagy is involved in ammonia homeostasis in vivo and that enhancement of hepatic autophagy increases ureagenesis by providing key urea-cycle intermediates and ATP. Importantly, pharmacological enhancement of autophagy protects against hyperammonemia resulting from both inherited and acquired causes. These findings may lead to development of new drugs promoting ammonia clearance in patients with hyperammonemia. Twit Text FOAVip Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29279371 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29279371 #FOAvip English Wikipedia <ref>{{Cite pmid|29279371}}</ref> Enhancement of hepatic autophagy increases ureagenesis and protects against hyperammonemia #MMPMID29279371 Soria LR; Allegri G; Melck D; Pastore N; Annunziata P; Paris D; Polishchuk E; Nusco E; Thöny B; Motta A; Häberle J; Ballabio A; Brunetti-Pierri N Proc Natl Acad Sci U S A 2018[Jan]; 115 (2): 391-6 PMID29279371show ga Waste nitrogen is converted into urea by the healthy liver. Systemic ammonia is elevated in patients with inherited urea-cycle disorders or acute and chronic liver diseases. Hyperammonemia is a challenging medical condition that holds high risks of mortality and irreversible brain damage. Current treatments are often inadequate. Autophagy is a lysosomal recycling pathway that plays a major role in metabolism. Here, we found that liver autophagy is involved in ammonia homeostasis in vivo and that enhancement of hepatic autophagy increases ureagenesis by providing key urea-cycle intermediates and ATP. Importantly, pharmacological enhancement of autophagy protects against hyperammonemia resulting from both inherited and acquired causes. These findings may lead to development of new drugs promoting ammonia clearance in patients with hyperammonemia. äEnhancement of hepatic autophagy increases ureagenesis and protects ag(epmc).pdf DeepDyve Pubget Overpricing