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10.1073/pnas.1717789115 http://scihub22266oqcxt.onion/10.1073/pnas.1717789115 C5776998!5776998!29282318     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (3): E458-67 Nephropedia Template TP {{tp|p=29282318|t=2018. SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR?t activity in a PKC-??dependent manner |pdf=|usr=}}{{29282318}} gab.com Text SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR t activity in a PKC- dependent manner JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29282318 #FOAvip Poor understanding of the mechanisms responsible for the development of IL-17+ and Foxp3+ cells prevents the development of potent clinical treatments to boost protective Th17 immunity and repress the pathogenic Th17 responses that induce autoimmunity. Here we show that SRC1 phosphorylated by TCR signaling kinase PKC-? functions as a coactivator in vivo to stimulate ROR?t activity by disrupting the binding of inhibitory Foxp3 and induce Foxp3 degradation. SRC1 is thus an important checkpoint downstream of TCR signals to promote the dominance of ROR?t over Foxp3 to establish an unopposed Th17 differentiation program. Our results thus provide a rationale for the development of SRC1-based treatments to control the scale of Th17 immunity by reciprocal shift of Th17 and T-regulatory cell differentiation. Twit Text FOAVip SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR t activity in a PKC- dependent manner ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29282318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29282318 #FOAvip English Wikipedia <ref>{{Cite pmid|29282318}}</ref> SRC1 promotes Th17 differentiation by overriding Foxp3 suppression to stimulate ROR?t activity in a PKC-??dependent manner #MMPMID29282318 Sen S; Wang F; Zhang J; He Z; Ma J; Gwack Y; Xu J; Sun Z Proc Natl Acad Sci U S A 2018[Jan]; 115 (3): E458-67 PMID29282318show ga Poor understanding of the mechanisms responsible for the development of IL-17+ and Foxp3+ cells prevents the development of potent clinical treatments to boost protective Th17 immunity and repress the pathogenic Th17 responses that induce autoimmunity. Here we show that SRC1 phosphorylated by TCR signaling kinase PKC-? functions as a coactivator in vivo to stimulate ROR?t activity by disrupting the binding of inhibitory Foxp3 and induce Foxp3 degradation. SRC1 is thus an important checkpoint downstream of TCR signals to promote the dominance of ROR?t over Foxp3 to establish an unopposed Th17 differentiation program. Our results thus provide a rationale for the development of SRC1-based treatments to control the scale of Th17 immunity by reciprocal shift of Th17 and T-regulatory cell differentiation. äSRC1 promotes Th17 differentiation by overriding Foxp3 suppression to (epmc).pdf DeepDyve Pubget Overpricing