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10.1073/pnas.1710437115 http://scihub22266oqcxt.onion/10.1073/pnas.1710437115 C5776966!5776966!29282323     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (3): E468-77 Nephropedia Template TP {{tp|p=29282323|t=2018. Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor |pdf=|usr=}}{{29282323}} gab.com Text Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29282323 #FOAvip Antibodies targeting PD-1 have elicited clinical responses in multiple tumors. Nevertheless, response to anti?PD-1 interventions is limited to a fraction of patients, and a comprehensive understanding of the signaling downstream of PD-1 could provide biomarkers for tumor response. We used affinity purification-mass spectrometry to uncover proteins associated with PD-1 and found that the adaptor protein SAP inhibits PD-1 functions by blocking the enzymatic interaction between the phosphatase SHP2 and the subset of its substrates that also bind to SAP. Signaling downstream of PD-1 in T cell subsets did not correlate with PD-1 expression but was inversely correlated with SAP levels. Thus, SAP is a modulator of PD-1 function and a potential biomarker for reduced responses to PD-1?based interventions. Twit Text FOAVip Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29282323 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29282323 #FOAvip English Wikipedia <ref>{{Cite pmid|29282323}}</ref> Affinity purification mass spectrometry analysis of PD-1 uncovers SAP as a new checkpoint inhibitor #MMPMID29282323 Peled M; Tocheva AS; Sandigursky S; Nayak S; Philips EA; Nichols KE; Strazza M; Azoulay-Alfaguter I; Askenazi M; Neel BG; Pelzek AJ; Ueberheide B; Mor A Proc Natl Acad Sci U S A 2018[Jan]; 115 (3): E468-77 PMID29282323show ga Antibodies targeting PD-1 have elicited clinical responses in multiple tumors. Nevertheless, response to anti?PD-1 interventions is limited to a fraction of patients, and a comprehensive understanding of the signaling downstream of PD-1 could provide biomarkers for tumor response. We used affinity purification-mass spectrometry to uncover proteins associated with PD-1 and found that the adaptor protein SAP inhibits PD-1 functions by blocking the enzymatic interaction between the phosphatase SHP2 and the subset of its substrates that also bind to SAP. Signaling downstream of PD-1 in T cell subsets did not correlate with PD-1 expression but was inversely correlated with SAP levels. Thus, SAP is a modulator of PD-1 function and a potential biomarker for reduced responses to PD-1?based interventions. äAffinity purification mass spectrometry analysis of PD-1 uncovers SAP (epmc).pdf DeepDyve Pubget Overpricing