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10.1073/pnas.1707936115 http://scihub22266oqcxt.onion/10.1073/pnas.1707936115 C5776960!5776960!29295928     free     free     free       Proc+Natl+Acad+Sci+U+S+A 2018 ; 115 (3): 537-42 Nephropedia Template TP {{tp|p=29295928|t=2018. Cargo navigation across 3D microtubule intersections |pdf=|usr=}}{{29295928}} gab.com Text Cargo navigation across 3D microtubule intersections JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29295928 #FOAvip Eukaryotic cells use microtubule (MT)-based transport to control the distribution of cargos across their complex and crowded environment. Prior models of MT-based motility considered cargo behavior on single filaments or simple networks. However, numerous recent reports revealed surprisingly complex 3D MT networks and associated complex cargo motility in cells. Such phenomena could not be modeled in previous studies. We show (via a recently developed experimental approach and in silico modeling) that network geometry plays a significant role in MT-based motility: The 3D properties of a single intersection can determine cargo routing, depending on cargo properties (e.g., size), opening the possibility that tuning 3D network geometry allows for selective targeting of cargos around the cell. Twit Text FOAVip Cargo navigation across 3D microtubule intersections ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29295928 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29295928 #FOAvip English Wikipedia <ref>{{Cite pmid|29295928}}</ref> Cargo navigation across 3D microtubule intersections #MMPMID29295928 Bergman JP; Bovyn MJ; Doval FF; Sharma A; Gudheti MV; Gross SP; Allard JF; Vershinin MD Proc Natl Acad Sci U S A 2018[Jan]; 115 (3): 537-42 PMID29295928show ga Eukaryotic cells use microtubule (MT)-based transport to control the distribution of cargos across their complex and crowded environment. Prior models of MT-based motility considered cargo behavior on single filaments or simple networks. However, numerous recent reports revealed surprisingly complex 3D MT networks and associated complex cargo motility in cells. Such phenomena could not be modeled in previous studies. We show (via a recently developed experimental approach and in silico modeling) that network geometry plays a significant role in MT-based motility: The 3D properties of a single intersection can determine cargo routing, depending on cargo properties (e.g., size), opening the possibility that tuning 3D network geometry allows for selective targeting of cargos around the cell. äCargo navigation across 3D microtubule intersections (epmc).pdf DeepDyve Pubget Overpricing