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10.1101/gad.305862.117

http://scihub22266oqcxt.onion/10.1101/gad.305862.117
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C5769772!5769772!29269483
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suck abstract from ncbi


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pmid29269483      Genes+Dev 2017 ; 31 (22): 2296-309
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  • RNA G-quadruplex secondary structure promotes alternative splicing via the RNA-binding protein hnRNPF #MMPMID29269483
  • Huang H; Zhang J; Harvey SE; Hu X; Cheng C
  • Genes Dev 2017[Nov]; 31 (22): 2296-309 PMID29269483show ga
  • Here, Huang et al. investigated the role of RNA secondary structure in splicing regulation and show that RNA elements with G-quadruplex-forming capacity promote exon inclusion. Analysis of RNA-binding protein footprints revealed that G quadruplexes are enriched in hnRNPF-binding sites and near hnRNPF-regulated alternatively spliced exons in the human transcriptome, thus providing new insights into the regulation of alternative splicing.
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