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10.1083/jcb.201706059 http://scihub22266oqcxt.onion/10.1083/jcb.201706059 C5748985!5748985 !29118025     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29118025 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2018 ; 217 (1 ): 117-126 Nephropedia Template TP {{tp|p=29118025 |t=2018. Specialized ribosomes and specific ribosomal protein paralogs control translation of mitochondrial proteins |pdf=|usr=}}{{29118025 }} gab.com Text Specialized ribosomes and specific ribosomal protein paralogs control translation of mitochondrial proteins JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29118025 #FOAvip Genome duplication in eukaryotes created paralog pairs of ribosomal proteins (RPs) that show high sequence similarity/identity. However, individual paralogs can confer vastly different effects upon cellular processes, e.g., specific yeast paralogs regulate actin organization, bud site selection, and mRNA localization, although how specificity is conferred is unknown. Changes in the RP composition of ribosomes might allow for specialized translation of different subsets of mRNAs, yet it is unclear whether specialized ribosomes exist and if paralog specificity controls translation. Using translatome analyses, we show that the translation of mitochondrial proteins is highly down-regulated in yeast lacking RP paralogs required for normal mitochondrial function (e.g., RPL1b). Although RPL1a and RPL1b encode identical proteins, Rpl1b-containing ribosomes confer more efficient translation of respiration-related proteins. Thus, ribosomes varying in RP composition may confer specialized functions, and RP paralog specificity defines a novel means of translational control. Twit Text FOAVip Specialized ribosomes and specific ribosomal protein paralogs control translation of mitochondrial proteins ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=29118025 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29118025 #FOAvip English Wikipedia <ref>{{Cite pmid|29118025 }}</ref> Specialized ribosomes and specific ribosomal protein paralogs control translation of mitochondrial proteins #MMPMID29118025 Segev N ; Gerst JE J Cell Biol 2018[Jan]; 217 (1 ): 117-126 PMID29118025 show ga Genome duplication in eukaryotes created paralog pairs of ribosomal proteins (RPs) that show high sequence similarity/identity. However, individual paralogs can confer vastly different effects upon cellular processes, e.g., specific yeast paralogs regulate actin organization, bud site selection, and mRNA localization, although how specificity is conferred is unknown. Changes in the RP composition of ribosomes might allow for specialized translation of different subsets of mRNAs, yet it is unclear whether specialized ribosomes exist and if paralog specificity controls translation. Using translatome analyses, we show that the translation of mitochondrial proteins is highly down-regulated in yeast lacking RP paralogs required for normal mitochondrial function (e.g., RPL1b). Although RPL1a and RPL1b encode identical proteins, Rpl1b-containing ribosomes confer more efficient translation of respiration-related proteins. Thus, ribosomes varying in RP composition may confer specialized functions, and RP paralog specificity defines a novel means of translational control. |Cell Proliferation/genetics [MESH] |Mitochondrial Proteins/*biosynthesis/genetics [MESH] |Protein Biosynthesis/*genetics [MESH] |Ribosomal Proteins/*genetics [MESH] |Ribosomes/genetics/metabolism [MESH] |Saccharomyces cerevisiae Proteins/*genetics [MESH] |Saccharomyces cerevisiae/*genetics/growth & development [MESH]Specialized ribosomes and specific ribosomal protein paralogs control (epmc).pdf DeepDyve Pubget Overpricing