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10.1083/jcb.201702184

http://scihub22266oqcxt.onion/10.1083/jcb.201702184
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C5748976!5748976!29133485
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suck abstract from ncbi


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pmid29133485      J+Cell+Biol 2018 ; 217 (1): 375-95
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  • Pyk2 and FAK differentially regulate invadopodia formation and function in breast cancer cells #MMPMID29133485
  • Genna A; Lapetina S; Lukic N; Twafra S; Meirson T; Sharma VP; Condeelis JS; Gil-Henn H
  • J Cell Biol 2018[Jan]; 217 (1): 375-95 PMID29133485show ga
  • The nonreceptor tyrosine kinase Pyk2 is highly expressed in invasive breast cancer, but how it potentiates tumor cell invasiveness is unclear. Genna et al. find that Pyk2 and the closely related kinase FAK modulate breast cancer cell invasiveness by distinct mechanisms and coordinate the balance between focal adhesion?mediated migration and invadopodia-dependent extracellular matrix invasion.
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