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Resolving the dark side of therapy-driven cancer cell death #MMPMID29263217
Bonavita E; Pelly VS; Zelenay S
J Exp Med 2018[Jan]; 215 (1): 9-11 PMID29263217show ga
In this issue of JEM, Sulciner et al. (https://doi.org/10.1084/jem.20170681) provide evidence that therapy-induced cancer cell death can, paradoxically, stimulate and accelerate the growth of surviving malignant cells by fueling tumor-promoting inflammation. Resolvins, a class of lipid mediators, counteract this effect, representing an attractive target for therapeutic intervention.