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10.18632/oncotarget.22452 http://scihub22266oqcxt.onion/10.18632/oncotarget.22452 C5746359!5746359!29299124     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (66): 109985-99 Nephropedia Template TP {{tp|p=29299124|t=2017. FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways |pdf=|usr=}}{{29299124}} gab.com Text FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29299124 #FOAvip Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor. High-risk NB is difficult to treat due to the lack of response to current therapies and aggressive disease progression. Despite novel drugs, alternative treatments and multi-modal treatments, finding an effective treatment strategy for these patients continues to be a major challenge. The current study focuses on examining the effects of FTY-720 or fingolimod, a drug that is FDA-approved for refractory multiple sclerosis, in NB. The results showed that FTY-720 regulates multiple pathways that result in various effects on calcium signaling, ion channel activation and cell survival/death pathways. FTY-720 rapidly inhibits TRPM7 channel activity, and inhibited TRPM7 kinase activity, modulates calcium signaling, induces a loss of mitochondrial membrane potential and opening of the mitochondrial permeability transition pore, and ultimately leads to cell death. Interestingly, the data also showed that low concentrations of FTY-720 sensitized drug-resistant NB cells to antineoplastic drugs. These results suggest that FTY-720 may be an attractive alternative for the treatment of NB. Twit Text FOAVip FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29299124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29299124 #FOAvip English Wikipedia <ref>{{Cite pmid|29299124}}</ref> FTY-720 induces apoptosis in neuroblastoma via multiple signaling pathways #MMPMID29299124 Lange I; Espinoza-Fuenzalida I; Ali MW; Serrano LE; Koomoa DLT Oncotarget 2017[Dec]; 8 (66): 109985-99 PMID29299124show ga Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor. High-risk NB is difficult to treat due to the lack of response to current therapies and aggressive disease progression. Despite novel drugs, alternative treatments and multi-modal treatments, finding an effective treatment strategy for these patients continues to be a major challenge. The current study focuses on examining the effects of FTY-720 or fingolimod, a drug that is FDA-approved for refractory multiple sclerosis, in NB. The results showed that FTY-720 regulates multiple pathways that result in various effects on calcium signaling, ion channel activation and cell survival/death pathways. FTY-720 rapidly inhibits TRPM7 channel activity, and inhibited TRPM7 kinase activity, modulates calcium signaling, induces a loss of mitochondrial membrane potential and opening of the mitochondrial permeability transition pore, and ultimately leads to cell death. Interestingly, the data also showed that low concentrations of FTY-720 sensitized drug-resistant NB cells to antineoplastic drugs. These results suggest that FTY-720 may be an attractive alternative for the treatment of NB. äFTY-720 induces apoptosis in neuroblastoma via multiple signaling path(epmc).pdf DeepDyve Pubget Overpricing