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10.1038/nature24283 http://scihub22266oqcxt.onion/10.1038/nature24283 C5743442!5743442!29072299     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nature 2017 ; 551 (7678): 105-9 Nephropedia Template TP {{tp|p=29072299|t=2017. Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation |pdf=|usr=}}{{29072299}} gab.com Text Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation JO: Nature http://www.kidney.de/pget.php?&tw=1&pmid=29072299 #FOAvip Th17 cells are critically involved in host defense, inflammation, and autoimmunity1?5. TGF-? is instrumental in Th17 differentiation by cooperating with IL-66,7. Yet, the mechanism of how TGF-? enables Th17 differentiation remains elusive. Here we reveal that TGF-? licenses Th17 differentiation by releasing Ski-Smad4-complex suppressed ROR?t expression. We found serendipitously that, unlike wild-type T cells, Smad4-deficient T cells differentiated into Th17 cells in the absence of TGF-? signaling in a ROR?t-dependent manner. Ectopic Smad4 expression suppressed the ROR?t expression and Th17 differentiation of Smad4-deficient T cells. Unexpectedly however, TGF-? neutralized Smad4 mediated suppression without affecting Smad4 binding to Rorc locus. Proteomic analysis revealed that Smad4 interacted with Ski, a transcriptional repressor degraded upon TGF-? stimulation. Ski controlled the histone acetylation/de-acetylation of Rorc locus and Th17 differentiation via Smad4 because ectopic Ski expression inhibited H3K9Ac of Rorc locus, Rorc expression and Th17 differentiation in a Smad4-dependent manner. Therefore, TGF-?-induced disruption of Ski releases Ski-Smad4 complex imposed suppression of ROR?t to license Th17 differentiation. This study reveals a critical mechanism by which TGF-? controls Th17 differentiation and uncovers Ski-Smad4 axis as a potential therapeutic target for treating Th17 related diseases. Twit Text FOAVip Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation ????Nature http://www.kidney.de/pget.php?&tw=1&pmid=29072299 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29072299 #FOAvip English Wikipedia <ref>{{Cite pmid|29072299}}</ref> Releasing Ski-Smad4 mediated suppression is essential to license Th17 differentiation #MMPMID29072299 Zhang S; Takaku M; Zou L; Gu Ad; Chou Wc; Zhang G; Wu B; Kong Q; Thomas SY; Serody JS; Chen X; Xu X; Wade PA; Cook DN; Ting JP; Wan YY Nature 2017[Nov]; 551 (7678): 105-9 PMID29072299show ga Th17 cells are critically involved in host defense, inflammation, and autoimmunity1?5. TGF-? is instrumental in Th17 differentiation by cooperating with IL-66,7. Yet, the mechanism of how TGF-? enables Th17 differentiation remains elusive. Here we reveal that TGF-? licenses Th17 differentiation by releasing Ski-Smad4-complex suppressed ROR?t expression. We found serendipitously that, unlike wild-type T cells, Smad4-deficient T cells differentiated into Th17 cells in the absence of TGF-? signaling in a ROR?t-dependent manner. Ectopic Smad4 expression suppressed the ROR?t expression and Th17 differentiation of Smad4-deficient T cells. Unexpectedly however, TGF-? neutralized Smad4 mediated suppression without affecting Smad4 binding to Rorc locus. Proteomic analysis revealed that Smad4 interacted with Ski, a transcriptional repressor degraded upon TGF-? stimulation. Ski controlled the histone acetylation/de-acetylation of Rorc locus and Th17 differentiation via Smad4 because ectopic Ski expression inhibited H3K9Ac of Rorc locus, Rorc expression and Th17 differentiation in a Smad4-dependent manner. Therefore, TGF-?-induced disruption of Ski releases Ski-Smad4 complex imposed suppression of ROR?t to license Th17 differentiation. This study reveals a critical mechanism by which TGF-? controls Th17 differentiation and uncovers Ski-Smad4 axis as a potential therapeutic target for treating Th17 related diseases. äReleasing Ski-Smad4 mediated suppression is essential to license Th17 (epmc).pdf DeepDyve Pubget Overpricing