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10.1038/s41564-017-0044-z http://scihub22266oqcxt.onion/10.1038/s41564-017-0044-z C5739288!5739288!29038467     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Microbiol 2018 ; 3 (1): 83-9 Nephropedia Template TP {{tp|p=29038467|t=2018. Self-sensing in Bacillus subtilis quorum-sensing systems |pdf=|usr=}}{{29038467}} gab.com Text Self-sensing in Bacillus subtilis quorum-sensing systems JO: Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=29038467 #FOAvip Bacterial cell-cell signaling, or quorum sensing, is characterized by the secretion and group-wide detection of small diffusible signal molecules called autoinducers. This mechanism allows cells to coordinate their behavior in a density-dependent manner. A quorum-sensing cell may directly respond to the autoinducers it produces in a cell-autonomous and quorum-independent manner, but the strength of such self-sensing effect and its impact on bacterial physiology are unclear. Here, we explored the existence and impact of self-sensing in the Bacillus subtilis ComQXP and Rap-Phr quorum-sensing systems. By comparing the quorum-sensing response of autoinducer-secreting and non-secreting cells in co-culture, we found that secreting cells consistently showed a stronger response than non-secreting cells. Combining genetic and quantitative analyses, we demonstrated this effect to be a direct result of self-sensing and ruled out an indirect regulatory effect of the autoinducer production genes on response sensitivity. In addition, self-sensing in the ComQXP system affected persistence to antibiotic treatment. Together, these findings indicate the existence of self-sensing in the two most common designs of quorum-sensing systems of Gram-positive bacteria. Twit Text FOAVip Self-sensing in Bacillus subtilis quorum-sensing systems ????Nat Microbiol http://www.kidney.de/pget.php?&tw=1&pmid=29038467 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29038467 #FOAvip English Wikipedia <ref>{{Cite pmid|29038467}}</ref> Self-sensing in Bacillus subtilis quorum-sensing systems #MMPMID29038467 Bareia T; Pollak S; Eldar A Nat Microbiol 2018[Jan]; 3 (1): 83-9 PMID29038467show ga Bacterial cell-cell signaling, or quorum sensing, is characterized by the secretion and group-wide detection of small diffusible signal molecules called autoinducers. This mechanism allows cells to coordinate their behavior in a density-dependent manner. A quorum-sensing cell may directly respond to the autoinducers it produces in a cell-autonomous and quorum-independent manner, but the strength of such self-sensing effect and its impact on bacterial physiology are unclear. Here, we explored the existence and impact of self-sensing in the Bacillus subtilis ComQXP and Rap-Phr quorum-sensing systems. By comparing the quorum-sensing response of autoinducer-secreting and non-secreting cells in co-culture, we found that secreting cells consistently showed a stronger response than non-secreting cells. Combining genetic and quantitative analyses, we demonstrated this effect to be a direct result of self-sensing and ruled out an indirect regulatory effect of the autoinducer production genes on response sensitivity. In addition, self-sensing in the ComQXP system affected persistence to antibiotic treatment. Together, these findings indicate the existence of self-sensing in the two most common designs of quorum-sensing systems of Gram-positive bacteria. äSelf-sensing in Bacillus subtilis quorum-sensing systems (epmc).pdf DeepDyve Pubget Overpricing