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10.4049/jimmunol.1700841 http://scihub22266oqcxt.onion/10.4049/jimmunol.1700841 C5736429!5736429!29150562     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29150562&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2018 ; 200 (1): 49-60 Nephropedia Template TP {{tp|p=29150562|t=2018. The role of MHC-E in T cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques |pdf=|usr=}}{{29150562}} gab.com Text The role of MHC-E in T cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29150562 #FOAvip Major histocompatibility complex E (MHC-E) is a highly conserved non-classical MHC-Ib molecule that predominantly binds and presents MHC-Ia leader sequence-derived peptides for natural killer cell regulation. However, MHC-E also binds pathogen-derived peptide antigens for presentation to CD8+ T cells. Given this role in adaptive immunity and its highly monomorphic nature in the human population, HLA-E is an attractive target for novel vaccine and immunotherapeutic modalities. Development of HLA-E-targeted therapies will require a physiologically relevant animal model that recapitulates HLA-E-restricted T cell biology. Here, we investigated MHC-E immunobiology in two common nonhuman primate species, Indian-origin rhesus macaques (RM) and Mauritian-origin cynomolgus macaques (MCM). Compared to humans and MCM, RM expressed a greater number of MHC-E alleles at both the population and individual level. Despite this difference, human, RM, and MCM MHC-E molecules were expressed at similar levels across immune cell subsets, equivalently up-regulated by viral pathogens, and bound and presented identical peptides to CD8+ T cells. Indeed, SIV-specific, Mamu-E-restricted CD8+ T cells from RM recognized antigenic peptides presented by all MHC-E molecules tested, including cross-species recognition of human and MCM SIV-infected CD4+ T cells. Thus, MHC-E is functionally conserved among humans, RM, and MCM, and both RM and MCM represent physiologically relevant animal models of HLA-E-restricted T cell immunobiology. Twit Text FOAVip The role of MHC-E in T cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29150562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29150562 #FOAvip English Wikipedia <ref>{{Cite pmid|29150562}}</ref> The role of MHC-E in T cell immunity is conserved among humans, rhesus macaques, and cynomolgus macaques #MMPMID29150562 Wu HL; Wiseman RW; Hughes CM; Webb GM; Abdulhaqq SA; Bimber BN; Hammond KB; Reed JS; Gao L; Burwitz BJ; Greene JM; Ferrer F; Legasse AW; Axthelm MK; Park BS; Brackenridge S; Maness NJ; McMichael AJ; Picker LJ; O?Connor DH; Hansen SG; Sacha JB J Immunol 2018[Jan]; 200 (1): 49-60 PMID29150562show ga Major histocompatibility complex E (MHC-E) is a highly conserved non-classical MHC-Ib molecule that predominantly binds and presents MHC-Ia leader sequence-derived peptides for natural killer cell regulation. However, MHC-E also binds pathogen-derived peptide antigens for presentation to CD8+ T cells. Given this role in adaptive immunity and its highly monomorphic nature in the human population, HLA-E is an attractive target for novel vaccine and immunotherapeutic modalities. Development of HLA-E-targeted therapies will require a physiologically relevant animal model that recapitulates HLA-E-restricted T cell biology. Here, we investigated MHC-E immunobiology in two common nonhuman primate species, Indian-origin rhesus macaques (RM) and Mauritian-origin cynomolgus macaques (MCM). Compared to humans and MCM, RM expressed a greater number of MHC-E alleles at both the population and individual level. Despite this difference, human, RM, and MCM MHC-E molecules were expressed at similar levels across immune cell subsets, equivalently up-regulated by viral pathogens, and bound and presented identical peptides to CD8+ T cells. Indeed, SIV-specific, Mamu-E-restricted CD8+ T cells from RM recognized antigenic peptides presented by all MHC-E molecules tested, including cross-species recognition of human and MCM SIV-infected CD4+ T cells. Thus, MHC-E is functionally conserved among humans, RM, and MCM, and both RM and MCM represent physiologically relevant animal models of HLA-E-restricted T cell immunobiology. äThe role of MHC-E in T cell immunity is conserved among humans, rhesus(epmc).pdf DeepDyve Pubget Overpricing