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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cold+Spring+Harb+Perspect+Biol 2018 ; 10 (4): ä Nephropedia Template TP
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Interleukin 17 Family Cytokines: Signaling Mechanisms, Biological Activities, and Therapeutic Implications #MMPMID28620097
Monin L; Gaffen SL
Cold Spring Harb Perspect Biol 2018[Apr]; 10 (4): ä PMID28620097show ga
The cytokines of the interleukin 17 (IL-17) family play a central role in the control of infections, especially extracellular fungi. Conversely, if unrestrained, these inflammatory cytokines contribute to the pathology of numerous autoimmune and chronic inflammatory conditions. Recent advances have led to the approval of IL-17A-blocking biologics for the treatment of moderate to severe plaque psoriasis, but much remains to be understood about the biological functions, regulation, and signaling pathways downstream of these factors. In this review, we outline the current knowledge of signal transduction and known physiological activities of IL-17 family cytokines. We will highlight in particular the current understanding of these cytokines in the context of skin manifestations of disease.