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Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Hum+Mol+Genet 2017 ; 26 (6): 1205-16 Nephropedia Template TP
gab.com Text
Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci #MMPMID28108556
Molineros JE; Yang W; Zhou Xj; Sun C; Okada Y; Zhang H; Heng Chua K; Lau YL; Kochi Y; Suzuki A; Yamamoto K; Ma J; Bang SY; Lee HS; Kim K; Bae SC; Zhang H; Shen N; Looger LL; Nath SK
Hum Mol Genet 2017[Mar]; 26 (6): 1205-16 PMID28108556show ga
We recently identified ten novel SLE susceptibility loci in Asians and uncovered several additional suggestive loci requiring further validation. This study aimed to replicate five of these suggestive loci in a Han Chinese cohort from Hong Kong, followed by meta-analysis (11,656 cases and 23,968 controls) on previously reported Asian and European populations, and to perform bioinformatic analyses on all 82 reported SLE loci to identify shared regulatory signatures. We performed a battery of analyses for these five loci, as well as joint analyses on all 82 SLE loci. All five loci passed genome-wide significance: MYNN (rs10936599, Pmeta?=?1.92?×?10?13, OR?=?1.14), ATG16L2 (rs11235604, Pmeta?=?8.87?×?10??12, OR?=?0.78), CCL22 (rs223881, Pmeta?=?5.87?×?10?16, OR?=?0.87), ANKS1A (rs2762340, Pmeta?=?4.93?×?10?15, OR?=?0.87) and RNASEH2C (rs1308020, Pmeta?=?2.96?×?10?19, OR?=?0.84) and co-located with annotated gene regulatory elements. The novel loci share genetic signatures with other reported SLE loci, including effects on gene expression, transcription factor binding, and epigenetic characteristics. Most (56%) of the correlated (r2?>?0.8) SNPs from the 82 SLE loci were implicated in differential expression (9.81?×?10?198?
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Confirmation of five novel susceptibility loci for systemic lupus eryt(epmc).pdf