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10.1126/science.aah5043 http://scihub22266oqcxt.onion/10.1126/science.aah5043 C5727343!5727343!28912244     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Science 2017 ; 357 (6356): 1156-60 Nephropedia Template TP {{tp|p=28912244|t=2017. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine |pdf=|usr=}}{{28912244}} gab.com Text Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine JO: Science http://www.kidney.de/pget.php?&tw=1&pmid=28912244 #FOAvip Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2?,2?-difluorodeoxycytidine) into its inactive form, 2?,2?-difluorodeoxyuridine. Metabolism was dependent on the expression of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria. In a colon cancer mouse model, gemcitabine resistance was induced by intra-tumor Gammaproteobacteria, dependent on bacterial CDDL expression, and abrogated by co-treatment with the antibiotic ciprofloxacin. Gemcitabine is commonly used to treat pancreatic ductal adenocarcinoma (PDAC), and we hypothesized that intra-tumor bacteria might contribute to drug resistance of these tumors. Consistent with this possibility, we found that of the 113 human PDACs that were tested, 86 (76%) were positive for bacteria, mainly Gammaproteobacteria. Twit Text FOAVip Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine ????Science http://www.kidney.de/pget.php?&tw=1&pmid=28912244 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912244 #FOAvip English Wikipedia <ref>{{Cite pmid|28912244}}</ref> Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine #MMPMID28912244 Geller LT; Barzily-Rokni M; Danino T; Jonas OH; Shental N; Nejman D; Gavert N; Zwang Y; Cooper ZA; Shee K; Thaiss CA; Reuben A; Livny J; Avraham R; Frederick DT; Ligorio M; Chatman K; Johnston SE; Mosher CM; Brandis A; Fuks G; Gurbatri C; Gopalakrishnan V; Kim M; Hurd MW; Katz M; Fleming J; Maitra A; Smith DA; Skalak M; Bu J; Michaud M; Trauger SA; Barshack I; Golan T; Sandbank J; Flaherty KT; Mandinova A; Garrett WS; Thayer SP; Ferrone CR; Huttenhower C; Bhatia SN; Gevers D; Wargo JA; Golub TR; Straussman R Science 2017[Sep]; 357 (6356): 1156-60 PMID28912244show ga Growing evidence suggests that microbes can influence the efficacy of cancer therapies. By studying colon cancer models, we found that bacteria can metabolize the chemotherapeutic drug gemcitabine (2?,2?-difluorodeoxycytidine) into its inactive form, 2?,2?-difluorodeoxyuridine. Metabolism was dependent on the expression of a long isoform of the bacterial enzyme cytidine deaminase (CDDL), seen primarily in Gammaproteobacteria. In a colon cancer mouse model, gemcitabine resistance was induced by intra-tumor Gammaproteobacteria, dependent on bacterial CDDL expression, and abrogated by co-treatment with the antibiotic ciprofloxacin. Gemcitabine is commonly used to treat pancreatic ductal adenocarcinoma (PDAC), and we hypothesized that intra-tumor bacteria might contribute to drug resistance of these tumors. Consistent with this possibility, we found that of the 113 human PDACs that were tested, 86 (76%) were positive for bacteria, mainly Gammaproteobacteria. äPotential role of intratumor bacteria in mediating tumor resistance to(epmc).pdf DeepDyve Pubget Overpricing