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10.1038/nrclinonc.2017.44 http://scihub22266oqcxt.onion/10.1038/nrclinonc.2017.44 C5720366!5720366!28397828     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28397828&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Clin+Oncol 2017 ; 14 (10): 611-29 Nephropedia Template TP {{tp|p=28397828|t=2017. EMT, CSCs, and drug resistance: the mechanistic link and clinical implications |pdf=|usr=}}{{28397828}} gab.com Text EMT, CSCs, and drug resistance: the mechanistic link and clinical implications JO: Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28397828 #FOAvip The success of anticancer therapy is usually limited by the development of drug resistance. Such acquired resistance is driven, in part, by intratumoural heterogeneity ? that is, the phenotypic diversity of cancer cells co-inhabiting a single tumour mass. The introduction of the cancer stem cell (CSC) concept, which posits the presence of minor subpopulations of CSCs that are uniquely capable of seeding new tumours, has provided a framework for understanding one dimension of intratumoural heterogeneity. This concept, taken together with the identification of the epithelial-to-mesenchymal transition (EMT) programme as a critical regulator of the CSC phenotype, offers an opportunity to investigate the nature of intratumoural heterogeneity and a possible mechanistic basis for anticancer drug resistance. In fact, accumulating evidence indicates that conventional therapies often fail to eradicate carcinoma cells that have entered the CSC state via activation of the EMT programme, thereby permitting CSC-mediated clinical relapse. In this Review, we summarize our current understanding of the link between the EMT programme and the CSC state, and also discuss how this knowledge can contribute to improvements in clinical practice. Twit Text FOAVip EMT, CSCs, and drug resistance: the mechanistic link and clinical implications ????Nat Rev Clin Oncol http://www.kidney.de/pget.php?&tw=1&pmid=28397828 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28397828 #FOAvip English Wikipedia <ref>{{Cite pmid|28397828}}</ref> EMT, CSCs, and drug resistance: the mechanistic link and clinical implications #MMPMID28397828 Shibue T; Weinberg RA Nat Rev Clin Oncol 2017[Oct]; 14 (10): 611-29 PMID28397828show ga The success of anticancer therapy is usually limited by the development of drug resistance. Such acquired resistance is driven, in part, by intratumoural heterogeneity ? that is, the phenotypic diversity of cancer cells co-inhabiting a single tumour mass. The introduction of the cancer stem cell (CSC) concept, which posits the presence of minor subpopulations of CSCs that are uniquely capable of seeding new tumours, has provided a framework for understanding one dimension of intratumoural heterogeneity. This concept, taken together with the identification of the epithelial-to-mesenchymal transition (EMT) programme as a critical regulator of the CSC phenotype, offers an opportunity to investigate the nature of intratumoural heterogeneity and a possible mechanistic basis for anticancer drug resistance. In fact, accumulating evidence indicates that conventional therapies often fail to eradicate carcinoma cells that have entered the CSC state via activation of the EMT programme, thereby permitting CSC-mediated clinical relapse. In this Review, we summarize our current understanding of the link between the EMT programme and the CSC state, and also discuss how this knowledge can contribute to improvements in clinical practice. äEMT, CSCs, and drug resistance: the mechanistic link and clinical impl(epmc).pdf DeepDyve Pubget Overpricing