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10.1016/j.brainresbull.2016.12.004 http://scihub22266oqcxt.onion/10.1016/j.brainresbull.2016.12.004 C5718625!5718625!28017782     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Brain+Res+Bull 2017 ; 133 (ä): 51-9 Nephropedia Template TP {{tp|p=28017782|t=2017. Parkin and PINK1 functions in oxidative stress and neurodegeneration |pdf=|usr=}}{{28017782}} gab.com Text Parkin and PINK1 functions in oxidative stress and neurodegeneration JO: Brain Res Bull http://www.kidney.de/pget.php?&tw=1&pmid=28017782 #FOAvip Loss-of-function mutations in the genes encoding Parkin and PINK1 are causally linked to autosomal recessive Parkinson?s disease (PD). Parkin, an E3 ubiquitin ligase, and PINK1, a mitochondrial-targeted kinase, function together in a common pathway to remove dysfunctional mitochondria by autophagy. Presumably, deficiency for Parkin or PINK1 impairs mitochondrial autophagy and thereby increases oxidative stress due to the accumulation of dysfunctional mitochondria that release reactive oxygen species. Parkin and PINK1 likely have additional functions that may be relevant to the mechanisms by which mutations in these genes cause neurodegeneration, such as regulating inflammation, apoptosis, or dendritic morphogenesis. Here we briefly review what is known about functions of Parkin and PINK1 related to oxidative stress and neurodegeneration. Twit Text FOAVip Parkin and PINK1 functions in oxidative stress and neurodegeneration ????Brain Res Bull http://www.kidney.de/pget.php?&tw=1&pmid=28017782 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28017782 #FOAvip English Wikipedia <ref>{{Cite pmid|28017782}}</ref> Parkin and PINK1 functions in oxidative stress and neurodegeneration #MMPMID28017782 Barodia SK; Creed RB; Goldberg MS Brain Res Bull 2017[Jul]; 133 (ä): 51-9 PMID28017782show ga Loss-of-function mutations in the genes encoding Parkin and PINK1 are causally linked to autosomal recessive Parkinson?s disease (PD). Parkin, an E3 ubiquitin ligase, and PINK1, a mitochondrial-targeted kinase, function together in a common pathway to remove dysfunctional mitochondria by autophagy. Presumably, deficiency for Parkin or PINK1 impairs mitochondrial autophagy and thereby increases oxidative stress due to the accumulation of dysfunctional mitochondria that release reactive oxygen species. Parkin and PINK1 likely have additional functions that may be relevant to the mechanisms by which mutations in these genes cause neurodegeneration, such as regulating inflammation, apoptosis, or dendritic morphogenesis. Here we briefly review what is known about functions of Parkin and PINK1 related to oxidative stress and neurodegeneration. äParkin and PINK1 functions in oxidative stress and neurodegeneration (epmc).pdf DeepDyve Pubget Overpricing