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10.1126/scitranslmed.aal2668 http://scihub22266oqcxt.onion/10.1126/scitranslmed.aal2668 C5718051!5718051 !28490664     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28490664 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Transl+Med 2017 ; 9 (389 ): ä Nephropedia Template TP {{tp|p=28490664 |t=2017. Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma |pdf=|usr=}}{{28490664 }} gab.com Text Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma JO: Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28490664 #FOAvip Multiple myeloma (MM) is a frequently incurable hematological cancer in which overactivity of MYC plays a central role, notably through up-regulation of ribosome biogenesis and translation. To better understand the oncogenic program driven by MYC and investigate its potential as a therapeutic target, we screened a chemically diverse small-molecule library for anti-MM activity. The most potent hits identified were rocaglate scaffold inhibitors of translation initiation. Expression profiling of MM cells revealed reversion of the oncogenic MYC-driven transcriptional program by CMLD010509, the most promising rocaglate. Proteome-wide reversion correlated with selective depletion of short-lived proteins that are key to MM growth and survival, most notably MYC, MDM2, CCND1, MAF, and MCL-1. The efficacy of CMLD010509 in mouse models of MM confirmed the therapeutic relevance of these findings in vivo and supports the feasibility of targeting the oncogenic MYC-driven translation program in MM with rocaglates. Twit Text FOAVip Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma ????Sci Transl Med http://www.kidney.de/pget.php?&tw=1&pmid=28490664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28490664 #FOAvip English Wikipedia <ref>{{Cite pmid|28490664 }}</ref> Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma #MMPMID28490664 Manier S ; Huynh D ; Shen YJ ; Zhou J ; Yusufzai T ; Salem KZ ; Ebright RY ; Shi J ; Park J ; Glavey SV ; Devine WG ; Liu CJ ; Leleu X ; Quesnel B ; Roche-Lestienne C ; Snyder JK ; Brown LE ; Gray N ; Bradner J ; Whitesell L ; Porco JA Jr ; Ghobrial IM Sci Transl Med 2017[May]; 9 (389 ): ä PMID28490664 show ga Multiple myeloma (MM) is a frequently incurable hematological cancer in which overactivity of MYC plays a central role, notably through up-regulation of ribosome biogenesis and translation. To better understand the oncogenic program driven by MYC and investigate its potential as a therapeutic target, we screened a chemically diverse small-molecule library for anti-MM activity. The most potent hits identified were rocaglate scaffold inhibitors of translation initiation. Expression profiling of MM cells revealed reversion of the oncogenic MYC-driven transcriptional program by CMLD010509, the most promising rocaglate. Proteome-wide reversion correlated with selective depletion of short-lived proteins that are key to MM growth and survival, most notably MYC, MDM2, CCND1, MAF, and MCL-1. The efficacy of CMLD010509 in mouse models of MM confirmed the therapeutic relevance of these findings in vivo and supports the feasibility of targeting the oncogenic MYC-driven translation program in MM with rocaglates. |Animals [MESH] |Cell Line, Tumor [MESH] |Cyclin D1/genetics [MESH] |Humans [MESH] |Mice [MESH] |Multiple Myeloma/*genetics/*therapy [MESH] |Proto-Oncogene Proteins c-maf/genetics [MESH] |Proto-Oncogene Proteins c-myc/genetics [MESH]Inhibiting the oncogenic translation program is an effective therapeut(epmc).pdf DeepDyve Pubget Overpricing