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10.1073/pnas.1716015114

http://scihub22266oqcxt.onion/10.1073/pnas.1716015114
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C5715788!5715788!29133417
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suck abstract from ncbi


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pmid29133417      Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (48): E10399-408
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  • Human resistin protects against endotoxic shock by blocking LPS?TLR4 interaction #MMPMID29133417
  • Jang JC; Li J; Gambini L; Batugedara HM; Sati S; Lazar MA; Fan L; Pellecchia M; Nair MG
  • Proc Natl Acad Sci U S A 2017[Nov]; 114 (48): E10399-408 PMID29133417show ga
  • Gram-negative bacterial sepsis is a life-threatening disease that is exacerbated by an uncontrolled immune response to the endotoxin lipopolysaccharide (LPS). Human resistin is a highly expressed cytokine in sepsis, where it is hypothesized to exacerbate inflammation. We identify an unexpected protective role for resistin in endotoxic shock. We use human resistin-expressing transgenic mice and human immune cell assays to show that resistin prevents LPS-induced mortality by blocking LPS binding to its receptor Toll-like receptor 4 (TLR4) and by promoting anti-inflammatory signaling. Helminth infection-induced resistin and treatment with recombinant resistin or resistin N-terminal peptides also inhibited LPS function. These studies report a protective function for resistin and identify the therapeutic potential of resistin-mediated anti-inflammatory pathways or resistin-based reagents in sepsis.
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